Therapeutics - Glaucoma 1

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  1. What is the conventional pathway for AH to exit into the circulatory system?
    Through trabecular meshwork to Schlemm’s canal
  2. What is the unconventional pathway for AH to exit into the circulatory system?
    Uveoscleral pathway through the base of the ciliary muscle to the uvea and out through the sclera
  3. What is the normal range for IOP in a healthy person?
    • ~15 mm Hg
    • 10-21 mm Hg
  4. What is the angle in glaucoma?
    Intersection of the cornea and iris
  5. Define Open angle glaucoma:
    Defect in drainage channels, narrowing and reducing the flow of aqueous humor
  6. Open angle glaucoma is usually uni or bi lateral?
    • Bilateral
    • Though progression may be different in each eye
  7. What are the goals of therapy for Open angle glaucoma?
    • QOL
    • Preserve visual fields
    • Minimize AE
    • Satbilize optic nerve
    • Proactive management
  8. What is the target pressure for glaucoma treatment?
    • AOA: 30-50% reduction
    • AAO: > or = to 25% reduction
  9. What is the MOA of BBs in Glaucoma treatment?
    Lowers production of AH
  10. What is the first line treatment for Open angle glaucoma?
    • BBs
    • Prostaglandin agonists
  11. What are the AEs for BBs in the treatment of Glaucoma?
    • Loss of visual acuity
    • Inflammation
    • Pain
    • Foreign body sensation
    • Hyperemia
    • Burning/stinging/tearing
  12. What are the CIs for BBs in the treatment of open angle glaucoma?
    • Sinus bradycardia
    • 2nd or 3rd degree atioventricular HB
    • Cardiogenic shock
    • Uncontrolled systolic HF
    • Non-selective: Asthma and COPD
  13. What is the Brand name for Carteolol?
    Ocupress
  14. What is the Brand name for Levobunolol?
    Betagon
  15. What is the Brand name for Metipranolol
    Optipranolol
  16. What is the Brand name for Timolol?
    Betimol, Istalol, Timoptic or Timolol-XE
  17. What is the Brand name for Betaxolol HCl
    • Betoptic
    • Betoptic S
  18. What are the non-selective BBs for Open angle glaucoma?
    • Cartelol (Ocupress)
    • Levobunolol (Betagan)
    • Metipranolol (Optipranolol)
    • Timolol (Betimol, Istalol, Timoptic, Timolol-XE)
  19. What are the B1 selective BBs for treatment of Open angle glaucoma?
    Betaxolol HCl (Betoptic and Betoptic S)
  20. What is the dosage form for Cartelol (Octupress)?
    1% solution
  21. What is the dosage form for Levobunolol HCl (Betagon)?
    0.25 or 0.5% solution
  22. What is the dosage form for Metipranolol (Optipranolol)?
    0.3% solution
  23. What is the dosage form for Timolol (Betimol, Istalol, Timoptic, Timolol-XE)?
    0.25 and 0.5% gel
  24. What is the dosage form for Betaxolol HCl (Betoptic)
    0.25 or 0.5% solution
  25. What is the dosage form for Betaxolol HCl (Betoptic S)
    0.25% suspension
  26. What are the Prostaglandin agonists?
  27. What is the MOA of prostaglandin agonists?
    • Promotes uvescleral outflow (unconventional pathway)
    • Bimatoprost also increases outflow through the TM (conventional pathway)
  28. What are the AE’s of local Prostaglandin agonists?
    • Common: Blurred vision, decreased acuity, itching/burngin/stinging, dry eyes, tearing, redness
    • Hyperpigmenttion and lengthening of eyelashes
  29. Which is more effective Bimatoprost or latanoprost?
    Bimatoprost
  30. If failed efficacy with travoprost or latanoprost, may switch to __________
    Bimatoprost
  31. Which prostaglandin agonist is available preservative-free solution.
    Tafluprost
  32. What is the brand name for Bimatoprost?
    Lumigan
  33. What is the brand name for Latanoprost?
    Xalatan
  34. What is the brand name for Travoprost?
    Travatan
  35. What is the brand name for Tafluprost?
    Zioptan
  36. What is the dosage form for Bimatoprost (Lumigan)?
    0.01% solution
  37. What is the dosage form for Latanoprost (Xalatan)?
    0.005% solution
  38. What is the dosage form for Travoprost (Travatan)?
    0.004%
  39. What is the dosage form for Tafluprost (Zioptan)?
    0.0015% solution
  40. Are BBs for Prostaglandin agonist a better choice for open angle glaucoma?
    AAO and AOA have no preference
  41. What is the MOA of Carbonic anhydrase inhibitors for the treatment of open angle glaucoma?
    Decrease production of AH
  42. What are the local carbonic anhydrase inhibitors used to treat open angle glaucoma?
    Brinzolamide (Azopt) and Dorzolamide (Trusopt)
  43. What is the dosage form of Brinzolamide (Azopt)?
    1% solution
  44. What is the dosage form of Dorzolamide HCl (Trusopt)?
    2% solution

Card Set Information

Author:
 kyleannkelsey
ID:
 281838
Filename:
 Therapeutics - Glaucoma 1
Updated:
 2014-09-01 20:30:43
Tags:
Therapeutics Glaucoma
Folders:
Therapeutics - Glaucoma 1
Description:
Therapeutics - Glaucoma 1
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