Therapeutics - RA 1
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What is the term for tissue proliferation of the synovial tissue in RA?
What are the physiological changes associated with RA?
- Loss of cartilage
- Chronic granulation scar tissue
- Tendon abnormalities
What immune cells invade synovial tissue, increase blood flow to the joint and promote tissue destruction?
Macrophages and T cells
Does RA usually have asymmetrical or symmetrical joint involvement?
Does OA usually have asymmetrical or symmetrical joint involvement?
What is Subluxation?
Incomplete or partial dislocation of a joint or organ
What is Synovitis?
Inflammation of the synovial membrane
What is Baker’s cyst?
Benign swelling of the popliteal bursa (located behind the knee)
Arthritic pain lasting <30 minutes indicates RA or OA?
Arthritic pain lasting >30 minutes indicates RA or OA?
What are the symptoms of RA?
- Joint pain for > 6 weeks
- Synovitis (worse in morning)
- Decreased appetite
- Low grade fever
- Joint deformity
What are the signs of RA?
- Joint tenderness, Erythema
- Joint swelling (Soft spongy)
- Rheumatoid nodules
- Grip weakness
- Joint subluxation and deformity
- Hammer toe
- Baker’s cyst
What vertebrae are most commonly affected in RA?
What vertebrae are most commonly affected in OA?
What hematological features are found in RA?
- Normochromic, Normocytic anemia
- Leukopenia or Leukocytosis
ESR and CRP are elevated or decreased in RA?
What characteristics would be present of a synovial aspiration sample in a patient with RA?
Turbidity and Leukocytosis
What Serology findings would indicate RA?
Rheumatoid factor (RF) or Anti-citrullinated protein antibody (ACPA)
Who should be tested for RA?
- Evidence of synovitis in at least 1 joint
- Not better explained by another diagnosis
What is the ACR/EULAR classification for RA based on?
- 0-10 point scale graded on the following:
- Joint involvement
- Acute phase reactions
- Duration of symptoms
- (> or = to 6 indicates RA)
What are the main areas of extra-articular involvement in RA?
- Pulmonary effusions/nodules/fibrosis
- Ocular keratoconjunctivitis sicca
How do you monitor RA?
- Sign and Symptom changes
- Laboratory monitoring of Drugs
What are the non-pharmacologic treatments for RA?
- Assistive devices
- Weight loss
What are the conventional pharmacologic treatments for RA?
What is the Janus kinase inhibitor Biologic agent used to treat RA?
What are the TNF-alpha antagonist Biologic agents used to treat RA?
- Infliximab (Remicade)
- Etanercept (Enbrel)
- Adalimumab (Humira)
- Cerolizumab pegol (Cimzia)
- Golimulab (Simponi)
What is the IL-1 receptor antagonist Biologic agent used to treat RA?
What is the IL-6 receptor antagonist Biologic agent used to treat RA?
What is the Co-stimulatory antagonist Biologic agent used to treat RA?
What is the brand name for Infliximab?
What is the brand name for Etanercept?
What is the brand name for Adalimumab?
What is the brand name for Cerolizumab pegol?
What is the brand name for Golimulab?
What is the brand name for Tofacitinib?
What is the brand name for Anakinra?
What is the brand name for Tocilizumab?
What is the brand name for Abatacept?
What is the brand name for Methotrexate?
Rheumatrex, Trexall, Rasuvo, Otrexup
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