Hemeoglobin and Myoglobin
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Describe the organic portion of the porphyrin ring.
- 4 pyrrole gropus
- 4 methyl groups
- 2 vinyl groups
- 2 propionates
Describe the 6 coordinated bonds to Fe in the heme.
- 4 nitrogens of the pyrrole rings
- 1 His93 (F8)
- 1 epty, o2, co,H2O
_____ reduces space forcing O2 to bind at an angle.
Distal histidine (E7)
What prevents the Fe in the heme group from oxidizing?
The non-polar environment
What are the three forms of of myoglobin and what are their 5th and 6th coordination positions?
Deoxymyoglobin(+2) 5: Hist F8 6: empty
Oxymyoglobin(+2) 5: Hist F8 6: O2
Ferrimyoglobin(+3) 5:Hist F8 6: H2O
What effect does the E7 Distal Histidine have on carbon monoxide?
It decreases the affinity
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