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Blocks sodium and myocardial potassium channels
- Pulseless/unstable V-Tach
- Cardiogenic shock
- Sinus brady
- 2nd/3rd degree AV blocks(unless functional pacemaker is available)
- Prolongation of the QRS and QT intervals
Recurrent life-threatening ventricular arrhythmias -
- V-Fib/Pulseless V-Tach unresponsive to CPR, defibrillation and vasopressors - 300mg IV/IO push. Initial dose may be followed one time within 3-5mins at 150mg IV/IO push
Max comulative dose is 2.2g/24hrs administered as - 150mg IV/IO over 10mins(15mg/min). May repeat rapid infusion (150mg IV/IO) every 10mins as needed
Perfusing Supraventricular and Ventricular Tachycardias -
- Refractory V-Fib or Pulseless V-Tach - 5mg/kg IV/IO bolus, which may be repeated up to a total dose of 15mg/kg per 24hrs. Max single dose 300mg
Loading dose 5mg/kg IV/IO over 20-60mins with max single dose of 300mg. Can be repeated to a max of 15mg/kg/day
Amiodarone drug interactions
- Use in conjuction with dig may cause dig toxicity.
- Antiarrhythmics may cause increase in serum glucose level.
- Beta and Calcium channel blockers may potentiate brady, sinus arrest and AV heart blocks.
Amiodarone special consideration
- Monitor pt for hypotension
- May worsen arrhythmia or precipitate new arrhythmia
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