PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Insulin)

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daynuhmay
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PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Insulin)
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2014-09-15 23:37:59
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diabetes pharmacology insulin
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diabetes pharmacology insulin
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  1. function of rapid-acting insulins
    mimic physiological post-prandial insulin secretion (normal mealtime insulin profile)
  2. list 3 types of rapid-acting insulins
    • 1) insulin lispro (Humalog)
    • 2) insulin aspart (Novolog)
    • 3) insuling glulisine (Apidra)
  3. onset of rapid-acting insulins
    15-30min
  4. peak time for rapid-acting insulins
    1-3 hrs
  5. duration of rapid-acting insulins
    3-4 hrs
  6. list short-acting insulins (2)
    • 1) Humulin R
    • 2) Novolin R
  7. onset of action for short-acting insulin
    .5-1 hr
  8. peak time for short-acting insulin
    2-4 hrs
  9. duration of short-acting insulin
    3-7 hrs
  10. which insulin is formulated ONLY with zinc?
    short-acting insulin
  11. name an intermediate-acting insulin
    • NPH (neutral protamine Hagedorn)
    • aka isophane insulin
    • Brand names: Humulin N, Novolin N
  12. onset of action of intermediate-acting insulin
    1-2 hrs
  13. peak time for intermediate-acting insulin
    6-10 hrs
  14. duration of intermediate-acting insulin
    16-20 hrs
  15. insulin that mimics basal insulin requirements
    long-acting insulin
  16. list 2 long-acting insulins
    • insulin glargine (Lantus)
    • insulin detemir (Levemir)
  17. onset of action of long-acting insulin
    1-2 hrs
  18. peak time for long-acting insulin
    ***NO PRONOUNCED PEAK***
  19. duration of long-acting insulin
    20-24 hrs
  20. which insulins should NOT be mixed in the same syringe with other insulins?
    long-acting insulins
  21. which insulin precipitates at physiological pH?
    insuline glargine (Lantus)
  22. MOA of insulin detemir (Levemir)
    binds reversibly to plasma albumin, allowing it to distribute slowly to peripheral tissues
  23. what combination of insulin is 70/30 or 50/50?
    NPH/regular (intermediate/short)
  24. what combination of insulin is Humalog Mix?
    NPL/lispro (intermediate/rapid)
  25. what combination of insulin is Novolog Mix?
    insulin aspart protamine/insulin aspart (intermediate/rapid)
  26. half-life of IV regular insulin
    9 minutes
  27. how is exogenous insulin metabolized?
    • 20-50% degraded by liver
    • 15-20% cleared by kidneys
  28. list SE's of insulin (4)
    • 1) hypoglycemia
    • 2) weight gain
    • 3) lipohypertrophy
    • 4) lipoatrophy

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