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PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)
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MOA of sulfonylureas
stimulate insulin release from pancreatic beta cells
bind to SU receptor -> close K+ channels -> membrane depol/Ca++ channels open -> Ca++ influx -> movement of insulin secretory granules to cell surface
list a 1st generation SU
chlorpropramide
list 3 2nd generation SU's
glipizide
glyburide
glimepiride
TRUE or FALSE?
1st generation SU's are generally lower in potency than 2nd gen, and are less effective at lowering glucose when administered at equipotent doses.
True
False
FALSE
All SU's are equally effective
metabolizes most SUs
CYP2C9
SUs are (highly/not) protein bound
highly (mainly to albumin)
SU excretion
active & inactive metabolites excreted in urine
list 2 meglitinides (short-acting insulin secretagogues)
repaglinide (Prandin)
nateglinide (Starlix)
MOA of meglitinides
stimulate insulin release from pancreatic beta cells
Author
daynuhmay
ID
283181
Card Set
PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)
Description
Diabetes Pharmacology sulfonylureas meglitinides
Updated
9/16/2014, 4:56:56 AM
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