PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)

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MOA of sulfonylureas

stimulate insulin release from pancreatic beta cells

bind to SU receptor -> close K+ channels -> membrane depol/Ca++ channels open -> Ca++ influx -> movement of insulin secretory granules to cell surface
list a 1st generation SU

chlorpropramide
list 3 2nd generation SU's
- glipizide
- glyburide
- glimepiride
TRUE or FALSE?

1st generation SU's are generally lower in potency than 2nd gen, and are less effective at lowering glucose when administered at equipotent doses.

FALSE

All SU's are equally effective
metabolizes most SUs

CYP2C9
SUs are (highly/not) protein bound

highly (mainly to albumin)
SU excretion

active & inactive metabolites excreted in urine
list 2 meglitinides (short-acting insulin secretagogues)
- repaglinide (Prandin)
- nateglinide (Starlix)
MOA of meglitinides

stimulate insulin release from pancreatic beta cells

Author:	daynuhmay
ID:	283181
Card Set:	PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)
Updated:	2014-09-16 04:56:56
Tags:	Sulfonylureas Meglitinides Diabetes Pharmacology
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Description:	Diabetes Pharmacology sulfonylureas meglitinides
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