PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)

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daynuhmay
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283181
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PHRD6095 Pharmacotherapy Lecture 2 - Diabetes Pharmacology (Sulfonylureas & Meglitinides)
Updated:
2014-09-16 00:56:56
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Sulfonylureas Meglitinides Diabetes Pharmacology
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Description:
Diabetes Pharmacology sulfonylureas meglitinides
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  1. MOA of sulfonylureas
    stimulate insulin release from pancreatic beta cells

    bind to SU receptor -> close K+ channels -> membrane depol/Ca++ channels open -> Ca++ influx -> movement of insulin secretory granules to cell surface
  2. list a 1st generation SU
    chlorpropramide
  3. list 3 2nd generation SU's
    • glipizide
    • glyburide
    • glimepiride
  4. TRUE or FALSE?

    1st generation SU's are generally lower in potency than 2nd gen, and are less effective  at lowering glucose when administered at equipotent doses.
    FALSE

    All SU's are equally effective
  5. metabolizes most SUs
    CYP2C9
  6. SUs are (highly/not) protein bound
    highly (mainly to albumin)
  7. SU excretion
    active & inactive metabolites excreted in urine
  8. list 2 meglitinides (short-acting insulin secretagogues)
    • repaglinide (Prandin)
    • nateglinide (Starlix)
  9. MOA of meglitinides
    stimulate insulin release from pancreatic beta cells

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