Therapeutics - Infectious disease 2

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kyleannkelsey
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283523
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Therapeutics - Infectious disease 2
Updated:
2014-09-21 13:31:34
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Therapeutics Infectious disease
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Therapeutics - Infectious disease
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  1. What are the peak levels for Aztreonam?
    90 ug/mL after 1 gram IV
  2. What is the half-life for Azreonam?
    • Normal renal function: 2 hours
    • Renal insufficiency: 6-8 hours
  3. What is the only Beta lactam that you can give after a person has had a PCN anaphylactic attack?
    Aztreonam
  4. What is a normal dose for Aztreonam?
    1-2 grams Q6-8H IV
  5. What is the brand name for Cefazolin?
    Ancef
  6. What is the brand name for Cephalexin?
    Keflex
  7. What is the brand name for Cefadroxil?
    Duracef
  8. What are the IV 1st generation cephalosporins?
    • Cefazolin – Ancef (IV)
    • Cephalexin – Keflex (oral)
    • Cefadroxil – Duracef (oral)
    • (zolexdrox)
  9. What are the oral 1st generation cephalosporins?
    • Cephalexin – Keflex (oral)
    • Cefadroxil – Duracef (oral)
  10. What are the IV 1st generation cephalosporins?
    Cefazolin – Ancef (IV)
  11. How are 1st generation cephalosporins eliminated?
    Renally
  12. What are the major uses for 1st generation cephalosporins (Cefazolin, Cephalexin, Cefadroxil)
    • Surgical prophylaxis
    • MSSA
    • E. coli
    • P. mirabilis UTI
    • Strep
  13. What is the normal dosing for Cefazolin (Ancef)?
    1-2 grams IV Q8H
  14. What is the normal dosing for Cephalexin (Keflex)?
    250-1000 mg Q6H PO
  15. What are the peak levels for Cefazolin (Ancef)?
    188 ug/mL after 1 gram IV
  16. What are the peak levels for Cephalexin (Keflex)?
    18 ug/mL after 500 mg IV
  17. What is the T1/2 for 1st generation cephaolosporins (Cefazolin, Cephalexin, Cephadroxil)?
    • Normal renal function: 2 hours
    • Renal insufficiency: 40-70 hours
  18. How should you monitor 1st generation cephaolosporins (Cefazolin, Cephalexin, Cephadroxil)?
    • Monitor for:
    • Renal insufficiency
    • BMS (if on long term therapy)
    • Diarrhea/c. diff (Do a CBC to watch for infection)
  19. When can you use cephaolosporins (Cefazolin, Cephalexin, Cephadroxil) if a person says they have had a PCN allergic reaction?
    Delayed hypersensitivity reactions like rashes, etc. (NOT ANAPHYLACTIC)
  20. What are the 2nd generation cephalosporins?
    • Cefuroxime (Zinacef, Ceftin)
    • Cefaclor (Ceclor)
    • Cefprozil (Cefzil)
    • Cefotetan (Cefoten)
    • Cefoxitin (Mefoxin)
    • (Profacfurofoxotetan)
  21. Which 2nd generation cephalosporins have particularly good anaerobic coverage and would be used for things like colorectal surgery?
    • Cefotetan (Cefotan)
    • Cefoxitin (Mefoxin)
  22. What type of microbe do no cephalosporinshave activity against?
    Enterococci
  23. What coverage do 2nd generation cephalosporins (Cefuroxime, Cefaclor, Cefprozil) have?
    • MSSA
    • Group A strep
    • S. pneumonia
    • Peptostreptococci
    • Some community acquired gram negative rods: N. gonorrheae, H. flu, E. coli (a little bit against K. pneumoniae)
  24. What coverage do 2nd generation cephalosporins (Cefotetan and Cefoxiten) have?
    • Similar to Cefuroxime with more B. fragilis activity (though still kind of poor, MIC = 32)
    • MSSA
    • Group A strep
    • S. pneumonia
    • Peptostreptococci
    • Some community acquired gram negative rods: N. gonorrheae, H. flu, E. coli (a little bit against K. pneumoniae)
  25. 2nd generation Cephalosporins are eliminated by what route?
    Renal
  26. What are the IV 2nd generation cephalosporins?
    • Cefuroxime
    • Cefoxitin
  27. What are the Oral 2nd generation cephalosporins?
    • Cefuroxime
    • Cefaclor
    • Cefprozil
  28. What are the 2nd generation cephalosporins (Cefuroxime, Cefaclor, Cefprozil, Cefoteten, Cefoxiten) mainly used for?
    • Anaerobic infections, like colon surgical prophylaxis (Mainly Cefoxiten)
    • Otits media or sinusitis (PO versions)
    • Streptococcal infections (Though there are better options)
  29. What is the normal dose of Cefoxitin?
    2grams IV Q6-8H
  30. What is the normal dose of Cefuroxime?
    • 0.75-1.5 grams IV Q6-8H
    • 250-500 mg Q8H PO
  31. What is the normal dose of Cefaclor?
    250-500 mg Q8H PO
  32. What is the normal dose of Cefprozil?
    250-500 mg Q12H PO
  33. How should you monitor 2nd generation cephaolosporins (Cefuroxime, Cefaclor, Cefprozil, Cefoteten, Cefoxiten)?
    • Same as first generation:
    • Monitor for:
    • Renal insufficiency
    • BMS (if on long term therapy)
    • Diarrhea/c. diff (Do a CBC to watch for infection)
    • Cefoxitin: has MTT side chain that interferes with Vit K, so watch PT/PTT

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