HIV

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Author:
LsRcU
ID:
283886
Filename:
HIV
Updated:
2014-09-23 11:17:29
Tags:
HIV
Folders:
PhilippineHeartCenter,Sept24
Description:
HIV
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  1. key parts attacked by HIV
    • T cellsĀ 
    • CD4 cells
  2. final stage of HIV infection
    AIDS
  3. treatment that can keep the level of HIV virus in your body level
    antiretroviral therapy
  4. the use of HIV medicine to fight HIV
    antiretroviral therapy
  5. 3 important genes required for replicating retrovirus
    • group-specific Ag proteins (gag)
    • Polymerase proteins (pol)
    • Envelope Proteins (env)
  6. code for core proteins
    group-specific Ag (gag) proteins
  7. Provide stability for the capsule
    Group-specific Ag (gag) proteins
  8. RNA-dependent DNA polymerase (reverse transcriptase) and endonuclease
    Polymerase proteins (pol)
  9. Important protein in the viral life cycle
    Polymerase proteins (pol)
  10. Glycoproteins that adhere to the target cell and produce cytopathic cell fusion
    Envelope proteins (env)
  11. Phase 0
    Infection
  12. Phase 1
    Window Period
  13. Phase 2
    Seroconversion
  14. Phase 3
    Latent Phase
  15. Phase 4
    Early Symptomatic
  16. Phase 5
    AIDS
  17. Phase where rapid viral replication but HIV test is negative
    Phase 1 Window Period
  18. Phase where Peak of viral load
    Positive HIV
    mild flu-like symptoms lasting 1-2wks
    Phase 2 Seroconversion
  19. Phase that is asymptomatic
    CD4 starts to go down
    lasts 1-15 yrs
    Phase 3 Laten Period
  20. What goes down in phase 3?
    CD4
  21. CD4 varies between 200-500
    lasts for 5 years
    + dermatologic
    + hematologic
    + mucocutaneous illness
    • Phase 4
    • Early Symptomatic
  22. Phase with CD4 <200
    lasts 2 yrs
    AIDS defining illness develops
    • Phase 5
    • AIDS
  23. 3 classes of drugs against HIV
    • Fusion Inhibitor
    • Reverse Transcriptase Inhibitor
    • Protease Inhibitor
  24. Representative drug for Fusion Inhibitor
    Enfuvirtide
  25. Representative drug for Reverse Transcriptase Inhibitor
    Zidovudine
  26. Representative drug for Protease Inhibitor
    Indinavir
  27. Drug class of Enfuvirtide
    Fusion Inhibitor
  28. Drug class of Zidovudine
    Reverse Transcriptase Inhibitor
  29. Drug class of Indinavir
    Protease Inhibitor
  30. Drug class that binds to gp41 subunit
    Fusion Inhibitor
  31. Drug class that inhibits HIV reverse transcriptase
    Reverse Transcriptase Inhibitor
  32. Drug class that Inhibits Viral Protein Processing
    Protease Inhibitor
  33. Representative drug that binds to gp41 subunit
    Enfuvirtide
  34. Representative drug that inhibits HIV reverse transcriptase
    Zidovudine
  35. Representative drug that inhibits viral protein processing
    Indinavir

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