What is the "first-pass effect" (of drugs)?
Conversely, what is Bioavailability?
Factors that impact rate of metabolism of drug.
Drugs that are metabolized IMMEDIATELY and not available for use.
*Oral only. Expressed as a %.
Bioavailability: % of drug available for use.
Factors: the drug, 1st pass effect, presence of hepatic enzymes that metabolize drugs.