1050: wk3 PPT2 for Exam 1

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Author:
xiongav
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284058
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1050: wk3 PPT2 for Exam 1
Updated:
2014-09-25 21:53:59
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Adrenergic Drugs
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  1. What nervous system do adrenergic agonist drugs mimic?

    How are adrenergic receptors on cells activated? (direct vs indirect)
    SNS.

    • Direct: drug binds w/ receptor on cell
    • Indirect: Promotes cell to release noreepinephrine (NE) --> activates adrenergic receptor.
    • Blocks NE reuptake
    • Inhibit inactivation of NE
  2. Categories of adrenergic agonist drugs:

    Catecholamines (epinephrine)
    -Why can one not take orally?
    -Does it cross the BBB?
    -Short/long duration?
    NO oral admin b/c: rapid inactivation is caused by liver enzymes and intestine.

    No, b/c it contains POLAR ions.

    Short duration
  3. Categories of adrenergic agonist drugs:

    Non-Catecholamines (albuteral)
    -Why can one take orally?
    -shorter or long duration?
    Orally is OK b/c it is NOT inactivated by liver & GI enzymes.

    -Longer duration
  4. What are the 4 adrenergic agonist receptors and what do they control?
    • 1) alpha 1: BV, eyes, heart
    • 2) alpha 2: CNS, & PNS
    • 3) beta 1: heart
    • 4) beta 2: lungs, uterus
  5. Alpha adrenergic receptors.

    Alpha 1: where are receptors located & how does it function?

    Adverse effects due to vasoconstriction?
    Receptors in SMOOTH MUSCLE (opens ion channels & allows Ca to enter).

    Vasoconstriction --> INcreased BP --> slows absorption of local anesthetic --> DEcreases nasal constriction --> dilates pupils.

    Adverse effects: necrosis, HTN -->barrel receptor activation --> bradycardia. 
  6. Alpha adrenergic receptors.

    Alpha 2: where receptors located & function?

    IN CNS, what does receptor activation cause?
    Located in BV & NS. In PNS, located in peripheral to prevent NE release.

    In CNS, DEcrease in SNS action on heart and BV --> DEcrease activity --> DEcrease pain.
  7. Beta adrenergic receptors.

    Beta 1:
    location&function?
    Benefits? (5)
    Adverse effects? (3)
    • Location: receptors in cardiac muscles.
    • Function: INcreases contraction, INcreases HR, INcrease speed of electrical conduction, INcrease renin production, INcrease BP --> INcrease cardiac output.

    Benefits: cardiac function, HR, shock, AV heart block, cardiac arrest.

    Adverse effects: tachycardia, dysrhythmia, angina in Pt w/ CAD.
  8. Beta adrenergic receptors.

    Beta 2: functions? (3)

    Relaxes? (3)

    *Beta 3: No drug association, NO receptors.
    • 1) Bronchodilation
    • 2) Vasodilation
    • 3) INc. glycogenolysis & gluconeogenisis in liver & DEcreases pancreatic insulin secretion.

    • Relaxes:
    • 1) Smooth muscle in uterus.
    • 2) urinary bladder
    • 3) GI tract
  9. Adrenergic drugs.

    *Can be selective OR non-selective in which receptors are stimulated.

    Is epinephrine sel/non-sel?
    -Acts on which adrenergic receptors? (3)

    Is albuterol sel/non-sel?
    -Acts on which adrenergic receptors? (1)
    • Epi. is NON-selective.
    • Acts on alpha & beta, and beta 2 receptors.

    • Alubuterol is Selective.
    • Acts on beta 2 receptors.

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