Unit 2 Pharmacology

any substance that modifies the body functions while taken

the study of chemicals that affect the body's functioning

named by original manufacture and active ingredient

brand name

• Oral 
• Topical
• Parenteral

Parenteral IV

effect of the body on the drug

• 1.  Absorption
• 2.  Distribution 
• 3. Metabolism 
• 4. Excretion

Process where a drug is transferred from the site of entry to the body to the blood stream. 

• Acid easier to absorb in stomach
• Basic(alkaline) better absorbed in sm. intestine

increased blood flow increased absorption

Large starting dose

lower dose for daily use

time required time for drug to elicit therapeutic response

concentration of drug in the blood that produces the desired effect w/o causing toxicity

highest concentration of the drug in the plasma after absorption is complete(time required for drug to reach maximum response)

lowest concentration in the blood( drawn 30 min before next dose)

amount of time it takes for 50% of the drug to be eliminated from the body

after absorption into the bloodstream the drug is distributed throughout the body

the change of the drug from its original form to a new form: change occurs in the liver

after drug is broken down by metabolism it is excreted from the body-kidneys do this.  Bad kidneys= slower excretion

• the process by which drugs alter cell physiology and affect the body
• ex. turn on or off or block or promote body responses