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Epinephrine: What kind of drug is it and how does it act?
Adrenergic agonist: What are its functions? (3)
Epinephrine is a SYMPATHETIC drug; acts to stimulate the SNS.
- 1) mimics action of SNS.
- 2) stimulates alpha&beta receptors.
- 3) Manages shock & anaphylactic reactions.
Nonselective adrenergic agonist.
-What are its 2 functions?
-Classification: therapeutic? pharmacologic?
-What are the two areas for non-adrenaline use?
- 1) stimulates alpha & beta receptors.
- 2) acts on cardiac & respiratory cells.
- (therapeutic): bronchodilater, antiasthmatic, vasopressor
- (pharmacologic): adrenergic.
Non-adrenaline: 1) asthma 2) cardiac stimulation.
Therapeutic effects? (2)
- 1) Acts on beta 1 (cardiac) & beta 2 (pulmonary)
- 2) Relaxes bronchial smooth muscle
- Therapeutic effects:
- 1) bronchodilation
- 2) maintains HR & BP
- Absorption: rapid via SQ, IM, IV, or inhalation.
- Dist: crosses placenta & enters breast milk. DOES NOT cross BBB.
Epinephrine: Metabolism & Excretion.
Where is it metabolized?
Where is it excreted?
- Metabolized in liver (quick).
- Excreted by kidney (rapid)
- 1) hypersensitivity
- 2) glaucoma
- 3) arrhythmia,
- 4) active labor
- 5) angina
- 6) HTN
- 7) diabetes
- 8) HF
Routes: 1) parenteral 2) topical 3) inhalent
Epinephrine: side effects (10)
- 1) nervousness
- 2) restlessness
- 3) tremors
- 4) bronchospasm w/ overuse of inhalers
- 5) N/V
- 6) agina
- 7) arrhythmia
- 8) HTN
- 9) tachcardia
- 10) hyperglycemia
Epinephrine: adverse effects (4)
- 1) Hypertensive crisis
- 2) subarachnoid hemorrhage
- 3) ventricular fibrillation shock
- 4) stroke
Epinephrine: interactions (drug-drug, drug-food)
- 1) HTN
- 2) bradycardia
- 1) cola nut
- 2) tea
- 3) coffee
- *Caffeine products INcrease effects.