Therapeutics - Infectious disease 8

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Author:
kyleannkelsey
ID:
284228
Filename:
Therapeutics - Infectious disease 8
Updated:
2014-09-27 18:02:50
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Therapeutics Infectious disease
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Therapeutics - Infectious disease
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Therapeutics - Infectious disease
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  1. How is Daptomycin (Cubicin) administered?
    IV only
  2. Is Daptomycin (Cubicin) bacteriocidal or static?
    Cidal
  3. What is the important PK/PD parameter for Daptomycin?
    Peak/MIC
  4. What are the SEs for Daptomycin (Cubicin)?
    • Elevated CPK
    • Eosinophilic pneumonia
  5. What are et main uses of Daptomycin (Cubicin)?
    • MRSA
    • Skin infections
    • Bacteremia
    • RIGHT sided endocarditis
  6. What is the dosing for Daptomycin (Cubicin)?
    • 4-6 mg/kg (TBW) IV Q12H
    • Doses up to 12 mg/kg have been tolerated
  7. What is the spectrum for Dalbavancin (Dalvance)?
    • No G –
    • Good for all G +, Including MRSA (0.06) and VRE (4)
  8. By what route is Dalbavancin (Dalvance) given?
    IV only
  9. What is the CI for Dalbavancin (Dalvance)?
    Pregnancy category C
  10. What is the important PK/PD parameter for Dalbavancin (Dalvance)?
    AUC/MIC
  11. What is the major use for Dalbavancin (Dalvance)?
    Skin/skin structure infections
  12. What is the dose for Dalbavancin (Dalvance)?
    1 gram x1 dose (30 minute infusion), then 500 mg x 1 on day 8
  13. What is the Peak for Dalbavancin (Dalvance)?
    287 ug/mL after a 1 gram dose
  14. What is the T1/2 for Dalbavancin (Dalvance)?
    346 hours
  15. What are the advantages of Dalbavancin (Dalvance)?
    • 2 doses for a full treatment (day1 and 8)
    • Reduces cost and keeps patients out of the hospital
  16. What is the brand name for Dalbavancin?
    Dalvance
  17. What is the brand name for Oritavancin?
    Orbactiv
  18. What is the spectrum for Oritavancin (Orbactiv)?
    • G + only
    • Good for all G + (VRE = 1)
  19. What is the CI for Oritavancin (Orbactiv)?
    Pregnancy Category C
  20. What is the important PK/PD parameter for Oritavancin (Orbactiv)?
    AUC/MIC
  21. What is the route of administration for Oritavancin (Orbactiv)?
    IV only
  22. What is the half life of Oritavancin (Orbactiv)?
    393 hours
  23. What is the peak conc. for Oritavancin (Orbactiv)?
    312 mcgml after a 1 gram dose (80.1 after single dose)
  24. What is the normal dosing for Oritavancin (Orbactiv)?
    1200 mg x 1 dose, infuse over 3 hours
  25. What is Oritavancin (Orbactiv) used for?
    Skin and skin structure infections
  26. What is the benefit of using Oritavancin (Orbactiv)?
    One time dose
  27. What is the spectrum for linezolid (Zyvox)?
    • No G -
    • Good for all G + (all 1s or 2s)
  28. What is the bioavailability of Linezolid (Zyvox)?
    100%
  29. What primary PK/PD for Linezolid (zyvox)?
    AUC/MIC
  30. Is Linezolid (Zyvox) bacteriostatic or cidal?
    Static
  31. What arethe main uses for Linezolid (Zyvox)?
    • MRSA
    • Enterococci infections (VRE)
    • Skin/Skin structure infections
  32. What is a normal dose of Linezolid (Zyvox)?
    600 mg IV or PO Q12H
  33. What is the major benefit of linezolid (Zyvox)?
    • 100% bioavailbility and both IV and PO
    • Easy step down therapy
  34. What is the major con to Linezolid (Zyvox)?
    It’s bacteriostatic so the immune system has to be intact
  35. What do you need to monitor for when giving Linezolid (Zyvox)?
    • Neutropenia & Thrombocytopenia – especially in ESRD – Do CBC
    • Optic neuropathy for long term therapy (~4 weeks)
    • Serotonin Syndrome with SSRIs, etc.
  36. What is the brand name for Tedizolid?
    Silvextro
  37. What is the spectrum of Tedizolid?
    • No G-
    • All G +, including C. diff
  38. By what route is Tedizolid (Silvextro) available?
    IV or PO
  39. How is Tedizolid (Silvextro) eliminated?
    Hepatically
  40. What is the primary PK/PD for Tedizolid (Silvextro) ?
    AUC/MIC
  41. What are the major uses for Tedizolid (Silvextro) ?
    • Gram + ifections, MRSA, MSSA, Enterococci, Group A strep
    • Skin and Skin structure infections (FDA approval)
    • HAP or VAP (maybe)
  42. What is a normal dose of Tedizolid (Silvextro)?
    200 mg IV Q24 hours
  43. What I steh peak level of Tedizolid (Silvextro)?
    • IV: 14.1 ug/mL after a 200 mg dose
    • PO: 2.3 mg/mL
  44. What is the half life for Tedizolid (Silvextro)?
    12.4 hours
  45. What is the bioavailability of Tedizolid (Silvextro)?
    >80%
  46. What is the brand name for clindamycin?
    Cleocin
  47. What is the spectrum for Clindamycin (Cleocin)?
    • Good: MSSA and strep
    • Poor: Enterococci, H. flu and B. fragilis
    • None: MRSA and G-s (other than B. fragilis/H. flu (4))
  48. By what route is Clindamycin (Cleocin) eliminated?
    Hepatically
  49. What are the routes of administration for Clindamycin (Cleocin)?
    IV or PO
  50. What is the primary PK/PD parameter for Clindamycin (Cleocin)?
    AUC/MIC

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