Therapeutics - Infectious disease 3 - flipped

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  1. dicloxacillin
    What are the Oral penicillinase resistant penicillins?
  2. MSSA
    Group A strep
    S. pneumonia
    According to the charts, what is thespectrum for penicillinase resistant penicillins (Nafcillin)?
  3. Gram – (including H. influenza)
    E. faecalis/faecium
    What microbes are outside of the spectrum of activity for Nafcillin/penicillinase resistant penicillins?
  4. MSSA
    Penicillinase resistant penicillins (Nafcillin/oxacillin/dicloxacillin/cloxacillin) are the drug of choice for what bug?
  5. 1-2 grams IV Q4H
    250-500 mg PO Q6H
    What is the normal dose for Penicillinase resistant penicillins (Nafcillin/oxacillin/dicloxacillin/cloxacillin)?
  6. Hepatically
    How is Nafcillin eliminated?
  7. 0.5 hours
    What is the half-life for Nafcillin/Dicloxacillin (Penicillinase resistant penicillins)?
  8. 90-94%
    What level of proteinbinding is exhibited by Nafcillin/Dicloxacillin (Penicillinase resistant penicillins)?
  9. 50-80 ug/mL for 1 gram IV
    10-15 ug/mL for 500 mg PO
    What arethe peack levels for Nafcillin/Dicloxacillin (Penicillinase resistant penicillins)?
  10. Neutropenia and Thrombocytopenia in treatments > 3 weeks
    Interstitial nephritis
    What are the side effects for Nafcillin/Dicloxacillin (Penicillinase resistant penicillins)?
  11. CBCs and WBCs for Neutropenia/thrombocytopenia when giving for a long duration (3-6 weeks)
    BMP (basic metabolic profile) and a rise in SCr for Interstitial nephritis
    What should you monitor for when giving Nafcillin/Dicloxacillin (Penicillinase resistant penicillins)?
  12. Ampicillin and sulbactam
    What is Unasyn?
  13. Amoxicillin and clavulanic acid
    What is Augmentin?
  14. Suicide inhibitors
    Sulbactam and clavulanic acid are what type of molecules?
  15. Group A strepS. pneumonia
    E. faecalis
    Some E. faecium
    Gram -: H. influ, N. gonorrheae, B. fragilis some Klebsiela
    What type of coverage do Unasyn have (chart)?
  16. No
    Ampicillin has no activity against StaphIs
    Unasyn active against MSSA?
  17. IV
    Unasyn is IV or PO?
  18. PO
    Augmentin is IV or PO?
  19. Pet bites
    Abdominal wounds
    Anything where anaerobes might be the infecting agent
    What is Unasyn or Augmentin the drug of choice for?
  20. 1.5-3 grams IV Q6H
    What is a normal dose of Unasyn?
  21. 500/125-875/125 mg PO Q8-12H
    XL dose: 1000/62.5 2 tabs BID
    What is the normal dose of Augmentin?
  22. Ampicillin:
    Normal renal activity: 1.3 hours
    Renal insufficiency: 5-20 hours
    Normal renal activity: 1.7 hours
    Renal insufficiency: 20 hours
    What is the half-life of Unasyn?
  23. Renally
    How is Unasyn eliminated?
  24. Piperacillin and Tazobactam
    What is Zosyn?
  25. Drug of choice for intra-abdominal infections/wounds and anaerobic infections
    What is the main use of Zosyn (piperacillin/tazobactam)?
  26. Group A strep
    S. pneumonia
    E. faecalis
    Gram – rods:
    N. gonorrhoeae
    E. coli
    B. fragilis
    Zosyn (piperacillin/tazobactam) has what coverage (chart)?
  27. IV only
    By what route of administration is Zosyn (piperacillin/tazobactam) available?
  28. Renally
    How is Zosyn (piperacillin/tazobactam) eliminated?
  29. Piperacillin: 
    Normal renal function: 1 hour
    Renally insufficient: 1 hour
    Normal renal function: 3-5 hours
    Renally insufficient: 3 hours
    What is the T1/2 for Zosyn (piperacillin/tazobactam)?
  30. 3.375 grams IV TID
    Infuse over 4 hours
    4.5 grams IV TID for empiric pseudomonas
    What is the normal dose of Zosyn (piperacillin/tazobactam)?
  31. Aztreonam (Azactam)
    Which antibiotic is the only available monobactam?
  32. Gram negative infections only
    What is Aztreonam (Azactam) used for in general (G+ or G-)?
  33. All G+
    What does Aztreonam (Azactam) have no activity against?
  34. Fairly good against nosocomial G- rods:
    H flu, N. gonorrhoeae, E. coli, K. pneumonia, S. marcescenesPseudomonas , though not often used for that indication
    What is the spectrum according to the charts for Aztreonam?
  35. Cystic fibrosisPseudomonas infectionPCN allergic patients (who had anaphylaxis to PCNs)
    What type sof G- infectionsis Aztreonam used for?
  36. What is the dose of Aztreonam?
    1-2 grams Q6-8H IV
Card Set:
Therapeutics - Infectious disease 3 - flipped
2014-09-29 13:49:08
Therapeutics Infectious disease flipped
Therapeutics - Infectious disease 3 - flipped
Therapeutics - Infectious disease 3 - flipped
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