Pharm test II.txt

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Author:
leitogonza
ID:
284572
Filename:
Pharm test II.txt
Updated:
2014-09-30 21:14:30
Tags:
opiods migranes
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    • author "me"
    • tags "opioid headaches ED"
    • folders ""
    • description ""
    • fileName "Pharm test II"
    • Opiods
    • General term for the most effective pain relievers available
  1. Opiate
    Applies only to compounds present in Opium
  2. Dyspnea
    Difficult or labored breathing
  3. Morphine action
    • - receptor involved
    • - pain relief
    • - Drowsiness
    • - Mental cloudiness
    • - Anxiety Reduction
    • - Sense of well being
  4. Morphine Pharmacokinetics
    • - administratio: PO, MI, subQ, Epidural, intrathecal.
    • - not very lipid soluble
    • - doesn't cross the BBB easily
    • - only small fraction of each dose reaches site of analgesic action
  5. Morphine therapeutic usage
    • - relief of pain (moderate to severe. > 7)
    • - Sedation
    • - Respiration depression
    • - Cough suppression
    • - Suppression of bowel motility
    • - pre-op treatment of anxiety
  6. Morphine side effects/adverse effects
    • - constipation
    • - urinary retention
    • - Dry mouth
    • - orthostatic hypotension
    • - respiratory depression (infants, elder)
    • (intensifies w CNS depressant such as alcohol, benzodiazapines)
    • (It's w impaired pulmonary function such as asthma, emphysema, etc)
  7. Morphine antagonist/antidote
    Naloxone (narcam)
  8. What type of drug is Fentanyl?
    Opioid
  9. Characteristics of fentanyl?
    • - 100 X more potent than morphine
    • - 3 routes: Parenteral (surgical anesthesia), transfermal (patch), transmucosal (buccal tabs)
  10. Give 3 names of opioids?
    • - Morphine
    • - Fentanyl
    • - Meperidine (demerol)
  11. What's are moderate to strong opioids?
    • - codeine
    • - oxycodone
    • - hydrocodone
  12. Agonist-antagonist opioids?
    • - work as antagonist in some receptors (mu) and agonist in others (kappa)
    • Examples:
    • - pentazocine (talwin)
    • - butorphanol (stadol)
  13. Name 2 non-opioid central acting analgesics:
    • - tramadol (ultram)
    • - clonodine (duralclom)
    • Alpha 2 acting
    • Cardiovascular problem (hypotension, bradycardia)
  14. Types o headaches?
    • - migraine
    • - cluster
    • - tensiĆ³n
  15. What is the mechanism of action of imitrex?
    Bind to the receptors on the intracranial blood vessels and activate serotonin causing vasodilation; also diminish perivascular inflammation.
  16. What are some drugs that relieve migraine headaches?
    • - sumatriptan (imitrex)
    • - all the triptans
    • - antiepilectic meds (topiramate-topomax)
  17. Drugs to prevent migranes?
    • - beta blockers (preferred drug for migraine prevention)
    • - calcium channel blockers (verapamil)
  18. What type of meds would u give a 1-3 pain scale?
    • Nonopioid
    • Nonpharmacologic (icepack)
  19. What type of drug would u give a 4-6 scale pain?
    • Nonopioid + weak opioid combination
    • Nonpharmacologic
  20. What type of drug would you give a 7-10 scale pain?
    Strong opioid +/- adjuvants
  21. How should you treat migraine headaches?
    Try nonanalgesic drugs first (aspirin, naproxen, or excedrin) and then migraine specific drugs (triptans)
  22. What to assess before giving a triptan or ergotamine?
    • - cardiovascular disease
    • - hypertension
    • - possible pregnancy
  23. Migranes could involve ...
    • - inflammation in the intracranial blood vessels
    • - therapy includes drugs and nonpharmocologic measures to prevent attacks
    • - therapy should start at the earliest sign of attack
  24. What's antiemetic?
    Drugs to prevent vomit
  25. What is prophilaxis?
    Action taken to prevent disease
  26. What are the adverse effects of sumatriptan (imitrex)
    • - chest symptoms (heavy arms & chest pressure)
    • - coronary vasospasm (rare angina secondary to vasospasm)
    • - others
  27. Types of sexual dysfunction
    • - may have both medical and psychological etiologies
    • - decreased Libido/reduced sex drive
    • - difficulty in arousal (erectile dysfunction in men) (and reduced vaginal lubrication in women)
    • - inability to have orgasm
    • - pain with sexual stimulation
    • - infertility
  28. Oral Drugs for ED?
    • - Sildenafil ( viagra)
    • - Vardenafil (levitra)
    • - tadalafil ( cialis)
  29. -afil meds are for?
    ED
  30. Tadalafil (Cialis) important characteristics?
    • - 17.5 hr half-life
    • - 36 hr duration of action
    • - 2013
    • - 2 hrs for median time to peak level
    • - no interaction with class I and III anti-dysrhythmic drug
  31. Sildenafil (viagra)
    • - 1998
    • - medial time to peak level 1 hr
    • - half-life 4 hrs
    • - duration of action 4 hr
    • - no interaction with class I and III anti-dysrhythmic drug
  32. Adverse rxn of sildenafil (viagra)
    • - hypotension
    • - Priapism (painful erections lasting more than 6 hrs)

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