To understand increase in reaction rates achieved by enzymes:
Assume that the transition state (X‡
) and the substrate are in equilibrium in which __ is the equilibrium constant for the formation of X‡
and v is the __.
The rate of the reaction v is proportional to the __
because only X‡
can be converted into product. The concentration of X‡
at equilibrium is in turn related to the __; the greater the difference in free energy between these two states, the __. Thus, the overall rate of reaction V depends on ΔG‡