Immuno - Lecture 2 - 1

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kyleannkelsey
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284931
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Immuno - Lecture 2 - 1
Updated:
2014-10-05 19:10:24
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Immuno Lecture
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Immuno - Lecture
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  1. Molecules which recognize antigens are:
    • B lymphocytes (antibodies)
    • TCR
    • T cell Receptors
  2. The T cell receptor (TCR) is composed of ____________which recognizes_____________. Its activation produces _______________.
    • membrane protein
    • the antigen
    • an immune response
  3. TCR antigen recognistion and the flowing immune response causes:
    • Development of CD4+ or CD8+ cells from the precursor T cells
    • (The process involves other receptors and downstream signal transduction)
  4. The TCR falls into two groups, what are they and what are their relative prevalence?
    • TCR1 (γδ) and TCR2 (αβ)
    • More than 95% of the TCR are TCR2
  5. Both types of T cells, TCR1 and TCR2 arise from ______________precursor cells.
    hematopoietic
  6. The structure of γδ TCR1 is similar to ________.
    TCR2.
  7. TCR1 and TCR2 differ in terms of:
    • The types of antigens recognized
    • The mode of antigen presentation
    • Recognition and signal transduction pathways
  8. Antigen recognition by TCR1 is similar to antigen recognition by antibodies, because they recognize _____________antigens.
    Unprocessed
  9. TCR-2 is a ____________with a molecular weight of _________ and is made up of two _____________chains.
    • heterodimer
    • 90kD
    • Peptide
  10. Each chain of a TCR-2 is composed of two distinct regions, what are they?
    Constant and variable regions.
  11. TCR-2 recognize ________________antigens in context of_____________.
    • membrane bound processed
    • MHC molecules
  12. The ability to recognize antigens depends on:
    The antibodies and the T cell receptors
  13. Both ______ and _____ are capable of recognizing antigens
    B cells and T cells
  14. Antibody and the ______________ have many features in common
    TCR
  15. B cells and T cells recognize antigens in very different or very similar manners?
    Different
  16. Antibodies recognize antigens in what situations?
    In solution and on B cell surface where antigen is in its native conformation.
  17. Antigens are not recognized by T cells in their ________ conformation
    Native
  18. Antigens need to be taken up by the antigen presenting cells before ________ will recognize them.
    T cells
  19. After uptake antigens are processed in the antigen presenting cell where they are…
    degraded and only a small piece of antigen is presented to the T cell
  20. The _________ on the T cell recognizes the antigen.
    • TCR
    • However, a third molecule, MHC, is also required for this process.

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