Immuno - Lecture 2 - 1
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Molecules which recognize antigens are:
- B lymphocytes (antibodies)
- T cell Receptors
The T cell receptor (TCR) is composed of ____________which recognizes_____________. Its activation produces _______________.
- membrane protein
- the antigen
- an immune response
TCR antigen recognistion and the flowing immune response causes:
- Development of CD4+ or CD8+ cells from the precursor T cells
- (The process involves other receptors and downstream signal transduction)
The TCR falls into two groups, what are they and what are their relative prevalence?
- TCR1 (γδ) and TCR2 (αβ)
- More than 95% of the TCR are TCR2
Both types of T cells, TCR1 and TCR2 arise from ______________precursor cells.
The structure of γδ TCR1 is similar to ________.
TCR1 and TCR2 differ in terms of:
- The types of antigens recognized
- The mode of antigen presentation
- Recognition and signal transduction pathways
Antigen recognition by TCR1 is similar to antigen recognition by antibodies, because they recognize _____________antigens.
TCR-2 is a ____________with a molecular weight of _________ and is made up of two _____________chains.
Each chain of a TCR-2 is composed of two distinct regions, what are they?
Constant and variable regions.
- TCR-2 recognize ________________antigens in context of_____________.
- membrane bound processed
- MHC molecules
The ability to recognize antigens depends on:
The antibodies and the T cell receptors
Both ______ and _____ are capable of recognizing antigens
B cells and T cells
Antibody and the ______________ have many features in common
B cells and T cells recognize antigens in very different or very similar manners?
Antibodies recognize antigens in what situations?
In solution and on B cell surface where antigen is in its native conformation.
Antigens are not recognized by T cells in their ________ conformation
Antigens need to be taken up by the antigen presenting cells before ________ will recognize them.
After uptake antigens are processed in the antigen presenting cell where they are…
degraded and only a small piece of antigen is presented to the T cell
The _________ on the T cell recognizes the antigen.
- However, a third molecule, MHC, is also required for this process.
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