Immuno - Cytokines - 3

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  1. Interferon ϒ is a potent activator of_____________________.
    mononuclear phagocytes

    • Interferon gamma increases MHC class _________ expression.
    • I and II
  2. Interferon gamma acts directly on ____ and _____ lymphocytes to promote their differentiation
    T and B
  3. _____________ activates neutrophils, upregulating their respiratory burst.
    Interferon gamma
  4. Interferon gamma stimulates the _____________ activity of NK cells.
  5. IFN-γ is an activator of________________, promoting CD4+ T lymphocyte adhesion and morphological alterations that facilitate______________.
    • vascular endothelial cells
    • lymphocyte extravasation
  6. Interleukin -5 is produced predominantly by ______ cells.
  7. IL-5 is activated by ________.
    Mast cells
  8. The major action of IL-5 is to:
    Stimulate the growth and differentiation of eosinophils.
  9. Eosinophils play a seminal role in the pathogenesis of allergic disease and asthma and are stimulated by:
  10. _______ activates mature eosinophils in such a way that they can kill helminths.
  11. High levels of IL-5 are found in:
    • Patients with:
    • Food and drug allergies,
    • Atopic dermatitis
    • Aspirin sensitivity
    • Allergic or non-allergic respiratory diseases
  12. Interleukin-12 is produced by activated_______ and __________.
    monocytes and B cells

    • _______ is the most potent NK cell stimulator known.
    • IL-12
  13. ________ stimulates the differentiation of naive CD4+ T cells to the TH1 subset.
  14. Colony Stimulating Factors are _________________
    A family of glycoproteins
  15. ______________ support hematopoietic colony formation.
    Colony Stimulating Factors
  16. ___________________ support the survival, proliferation and maturation of hematopoietic progenitor cells and modulate the function of____________________.
    • Colony Stimulating Factors
    • mature effector cells
  17. ________________ prevents chemotherapy-induced neutropenia.
    Colony Stimulating Factors
  18. ___________________ stimulates haemopoiesis in marrow failure.
    Colony Stimulating Factors
  19. _________________ assists in marrow transplantation.
    Colony Stimulating Factors
  20. _________________ augments effector cell function and stimulates monocyte's anticancer effects.
    Colony Stimulating Factors
  21. Granulocyte-CSF is secreted by_____________, ______________ and ___________________.
    macrophages, endothelium and leukocytes
  22. Granulocyte-CSF stimulates bone marrow to produce _______________and then direct their migration to the peripheral blood.
  23. _______________ is a growth factor for the proliferation, differentiation, effector function and survival of neutrophils.
  24. ______________ causes proliferation of endothelial cells and enhances phagocytic activity of neutrophils.
  25. ________________ results in reactive oxygen intermediate production my neutrophils.
  26. Granulocyte-CSF causes _____________________ -dependent cellular toxicity by neutrophils.
  27. Filgrastim is __________ produced by recombinant DNA technology.
  28. Filgastim is administered to patients receiving _____________________for advanced cancer.
    cytotoxic chemotherapy
  29. Filgrastim causes a dose-dependent amelioration of _______________ associated with cancer-chemotherapy.
  30. _________________ has been well tolerated and may reduce the morbidity and mortality rate associated with chemotherapy.
  31. ______________ permits the use of high doses of cytotoxic agents and a greater anti-tumor response.
  32. GM-CSF is produced by____________________________________________________.
    macrophages, T cells, mast cells, fibroblasts, and endothelial cells
  33. GM-CSF stimulates stem cells to produce__________________ and _________________.
    neutrophils and monocytes
  34. Monocytes migrate into tissues and differentiate into___________________.

    • Sargramostim is a human recombinant______________.
    • GM-CSF
  35. Sargramostim has beneficial effects on _________________in patients receiving high dose chemotherapy when receiving ____________________________or in advanced cancers.
    • bone marrow function
    • autologous bone marrow transplantation
  36. _______________________ has also been used in AIDS, myelodysplastic syndrome, and aplastic anemia in an attempt to stimulate bone marrow function.
  37. High doses of __________________ have produced marked weight gain, generalized edema and hypotension.
  38. ________________ also causes a dose dependent, asymptomatic eosinophilia.
    GM-CSF (Sagramostim)
  39. Interleukin 11 is produced by_________________.
    bone marrow stroma
  40. _____________ activates B cells, plasmacytomas, hepatocytes and megakaryocytes.
  41. ______________ plays a role in bone cell proliferation, increases platelet levels after chemotherapy.
  42. IL-11 also modulates ___________________responses.
  43. _________________ promotes differentiation of progenitor B cells and megakaryocytes.
  44. What is the brand name for Oprelvekin?
  45. ___________________ is recombinant human IL-11.
    Oprelvekin (Neumega)
  46. Oprelvekin (Neumega) is used to stimulate ______________________________in patients undergoing chemotherapy.
    bone marrow to induce platelet production
  47. bone marrow to induce platelet production is administered by___________________, usually ____________ hours after chemotherapy.
    • subcutaneous injection
    • 6-24
  48. Oprelvekin (Neumega) has a half life of about _______ hours.
  49. The common side effects of Oprelvekin (Neumega) include:
    Fluid retention, tachycardia, edema, nausea, vomiting and shortness of breath
Card Set:
Immuno - Cytokines - 3
2014-10-09 01:58:50
Immuno Cytokines
Immuno - Cytokines - 3
Immuno - Cytokines - 3
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