Immuno - Cytokines - 4

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  1. IL-2 increases the ___________capacity of natural killer cells.
  2. At high doses IL-2 produces _______cells which kill a much wider range of targets including the tumor cells
  3. The quality of ____________ synthesized by activated CD4+ T cells is an important determinant of the magnitude of T cell-dependent immune responses.
  4. IL-2 is the major growth factor for ________________.
    T lymphocytes
  5. IL-2 stimulates the growth of ___________and enhances their cytolytic function.
    NK cells
  6. The three distinct subunits of the IL-2 receptor are:
    α, β and γ chains.
  7. The IL-2 receptor occurs in three forms with different______________.
    affinities for IL-2
  8. The ______ chain of IL-2 receptors is expressed by activated, but not by resting T cell.
  9. _________ is often referred to as the TAC (T cell activation) antigen.
    Alpha chain of the IL-2 receptor
  10. Signal transduction by the IL-2 receptor requires both the________________, but the trimeric receptor which also contains___________, binds IL-2 with high affinity.
    • β and γ chains
    • α chain
  11. When IL-2 binds to high-affinity receptors, it becomes ______________ following receptor-mediated endocytosis.
  12. Internalization of IL-2 after binding its receptor causes stimulation of _______________turnover.
  13. IL-2 stimulates redistribution of ________________from the cytoplasm to cell membrane.
    protein kinase C
  14. Binding of IL-2 to cell surface receptors stimulates the IL-2 receptor gene resulting in:
    An increased expression of IL-2 receptors, with low affinity receptors being preferentially increased
  15. Proleukin is a _______________that is used for the treatment of ___________________, ________________ and _____________.
    • recombinant human IL-2
    • cancer (renal cell carcinoma, advanced malignant melanoma, acute myelogenous leukemia), AIDS and increases remission period in patients given bone marrow transplants.
  16. Proleukin’s half life is ___________and therefore is given as_________ or _____________.
    • Short
    • a continuous infusion
    • multiple intermittent doses
  17. __________ is a regulator of allergic reactions.
  18. Interleukin-4 is a ______ cell derived cytokine
  19. The most frequent side effects of Proleukin are:
    • Fever, chills, fatigue, malaise, nausea and vomiting
    • It has also been associated with capillary leak syndrome.
  20. _____________is required for the production of IgE and is the principal cytokine that stimulates switching of B cells to IgE production.
  21. IL-4 is a growth and differentiation factor for ___________ subset.
  22. ________ is a growth factor for mast cells.
  23. IL-4 stimulates the expression of certain adhesion molecules, notably ___________________________on endothelial cells.
    vascular cell adhesion molecule-1 (VCAM-1)
  24. The activation of TH2 cells is often associated with a suppression of__________________________________________.
    macrophage-mediated immune reactions
  25. __________ inhibits macrophage activation and blocks most of the macrophage activating effects of IFN-γ, including increased production of cytokines such as IL-1, nitric oxide and prostaglandins.
  26. Interleukin-9 is secreted by _________ cells.
  27. __________ promotes the survival of primary mast cells.
  28. IL-9 is an inducer of ______ production.
  29. IL-9 promotes the expression of ____________ receptors.
    high affinity IgE
  30. IL-9 induces inflammation and enhances _________________ in asthmatic airways.
    mucus hyper-secretion
  31. ________ promotes eosinophil maturation in synergy with IL-5.
  32. ____________ is an essential cytokine in asthmatic disease.
  33. Interleukin-13 is secreted by ______cells.
  34. __________ inhibits Th1 responses.
  35. __________ causes isotype switching from IgG to IgE, inhibits inflammatory cytokines, and enhances MHC class II expression.
  36. IL-13 regulates______________,________________,______________ and ________________.
    mucus production, inflammation, fibrosis and tissue remodeling
  37. IL-13 is a therapeutic target for a number of disease states including:
    Asthma and idiopathic pulmonary fibrosis
  38. ___________ is also an inducer of adhesion molecules involved in asthma.
Card Set:
Immuno - Cytokines - 4
2014-10-09 02:02:15
Immuno Cytokines
Immuno - Cytokines - 4
Immuno - Cytokines - 4
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