Cell Biology 7 - Secretion
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What is secretion?
The manufacture and release of useful products from a cell.
What happens in secretion?
Cells take small molecules from the bloodstream, transform them by intracellular mechanisms to complex functional molecules, and then release them into the cells' external environment.
What are some typical secretory products?
The extracellular matrix: Collagens etc -structural support
Exocrine glands: Saliva, pancreatic juice, sweat, mucus etc.
Endocrine products: hormones
Plasma Proteins: albumens, blood clotting proteins, antibodies.
Lysosomal pathway and membrane proteins - use the secretory pathway, but not released from cell
What is the secretory pathway?
How was the secretory pathway discovered?
What is endoplasmic reticulum?
What is the rough endoplasmic reticulum?
Membrane of bound cisternae, with ribosomes on the outside
What is the smooth endoplasmic reticulum?
It is a network of interconnecting tubules, with no ribosome, connected to the RER.
How do proteins get into the rough endoplasmic reticulum?
What is the function of the Endoplasmic reticulum - Rough and Smooth?
What is the Golgi Apparatus?
What are the functions of the Golgi?
Receives vesicle traffic from the ER - Proteins, membrane and membrane proteins.
Further Quality Control - Sends faulty materials back to the ER
Complex glycosilation reaction - Adds sugars to proteins
Sorting and packaging of contents
Targeting of products to final destination.
What is the fate of the products from the Golgi?
How is sorting and packaging accomplished in the Golgi?
What determines which secreted vessels go where?
The cell has specific targeting systems which ensures that vessels go to the correct surface
It was discovered from viral behaviour.
What happens when a vesicle is delivered to a cell surface?
They are released from the cell by exocytosis.
What is the function of secretory vesicles?
Concentration of contents
Targeting and transport to cell surface/lysosome
Membrane fusion and release of product
Delivery of new membrane lipids and proteins to cell surface.
How can mistargetting of vesicles be related to disease?
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