Mutations in beta chains of hemoglobin
When hemoglobin is deoxygenated, beta chains link together
⇢forming long protein rods
that make the cell "sickle"
, more likely to occur in lung/pulmonary disease, is an exacerbating factor for increased sickling and vessel occlusion
because of its shape
, it can get caught on each other and cause a log jam
which would hinder the tissue on the other side from getting the blood and oxygen.
- cold, stress, infection, physical exertion=more necessity of oxygen use
: sickle cell trait; may not have symptoms enough to know they have it.
: sickle cell disease
- Factors associated with sickling: cold, stress, physical exertion, infection, sleep, illnesses that cause hypoxia, dehydration, or acidosis