Immunology

Card Set Information

Author:
nextMD
ID:
286613
Filename:
Immunology
Updated:
2014-10-22 01:38:25
Tags:
Immunology
Folders:
Immunology
Description:
Hypersensitivity
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  1. Th1
    • IFgamma
    • intracellular microbes
  2. Th2
    • interleukin-4 (IL-4)
    • interleukin-5 (IL-5)
  3. interleukin-4 (IL-4)
    stimulates IgE - basis of allergic reactions
  4. interleukin-5 (IL-5)
    activates eosinophils - defense against parasites
  5. Th17
    • IL-17
    • IL-22
  6. IL-17 & IL-22
    Extracellular bacteria, fungi - stimulate inflammation, neutrophil and monocyte recruitment
  7. Immediate - Type I
    • IgE antibody
    • Mast cells and mediators
  8. Antibody Mediated - Type II
    IgM, IgG antibodies against cell surface or ECM antigens - Opsonization, phagocytosis, complement, fc receptor mediated recruitment, activation of leukocytes
  9. Immune Complex - Type III
    Immune complexes of circulating antigens and IgM or IgG - complement Fc receptor mediated recruitment and activation of leukocytes
  10. T-cell mediated - Type IV
    • CD4 T-cells (delayed hypersensitivity)
    • CD8 CTL's (T-cell mediated cytolysis)
  11. CD4 T-cells (delayed hypersensitivity)
    macrophage activation, cytokine mediated activation
  12. CD8 CTL's (T-cell mediated cytolysis)
    direct target cell killing, cytokine mediated activation

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