Pharmacokinetics

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Author:
nextMD
ID:
286614
Filename:
Pharmacokinetics
Updated:
2014-10-22 02:31:37
Tags:
Pharmacokinetics
Folders:
Pharmacokinetics
Description:
Pharmacokinetics
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  1. F - Bioavailability
    Fraction of administered dose that reaches systemic circulation
  2. F - Bioavailability formula
    • F = AUC(route)/AUC (IV)
    • [no units]
  3. Vd
    Volume of distribution describes the drug's ability to distribute from blood throughout the body
  4. Vd formula
    • Vd(apparent) = amount of drug in body/ (Cp)
    • [L/kg]
  5. Cp
    Concentration of drug in plasma
  6. Elimination
    Amount of drug removed from body per unit time
  7. Elimination formula
    • Amount of drug removed from body/time
    • [mg/hr]
  8. Cl
    Clearance is the amount of plasma from which the "total body" can remove the drug per unit time
  9. Cl formula
    • Cl = rate of elimination / (Cp)
    • [L/hr]
  10. t1/2
    Half life is the time it takes form plasma concentration of drug to reach 1/2 it's original concentration at time zero
  11. t1/2 formula
    • t1/2 = 0.693 * Vd / Cl
    • [time units]
  12. LD - loading dose
    LD = Vd* Cp / F
  13. MD - maintenance dose
    MD= Cl* Cp / F
  14. How many 1/2 lives to steady state (1st order)
    ~4-5
  15. Drugs with zero order kinetics
    • Ethanol
    • Aspirin
    • Phenytoin
  16. CYP450 Inducers
    • Phenytoin CYP2C8-10
    • Rifampin CYP2C8-10
    • St. John's Wort CYP3A
  17. CYP450 Inhibitors
    • Ketoconazole CYP3A
    • Erythromycin CYP3A
    • Grapefruit Juice CYP3A

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