The generation of __ from __ leads to the activation of other __
The structural changes accompanying the activation of __are different from __
Four stretches of polypeptide, constituting 15% of the molecule, changes markedly on __
These regions are flexible in the __, whereas they have a well-defined conformation in __.
The oxyanion hole in trypsinogen is too far from histidine 57 to promote the formation of the tetrahedral transition state