immune system

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  1. Innate Imunne system:
    Also known as non specific is the first line of defense. We were born with it, doesn't have antibodies.
  2. Inflammatory response: innate immunity
    second line of defense to injury or infection immediate broadly specific.
  3. Adaptive immunity:
    Third line of defense in response to antigen exposure, very specific, lymphocyte system, t and b lymphocytes
  4. Vascularized tissue:
  5. Inflammation physiologic:
    • localization: prevents spreading
    • REcruitment
  6. Inflammation pathologic:
    • acute inflammation save your life
    • chronic can damage tissue 2 weeks death
  7. Leukocyte: 1st innate
    1st responder, most abundant, phagocytosis, chemotaxis, 1st 24 hours, not specific, diapedisis, pus.
  8. Macrophage: monocyte
    after 24 hours, diapedisis, before no inflammation.
  9. Mast cell:
    • proinflammatory, produces histamine, most powerful cell. degranulation, constriction of smooth muscle, they activate ARACHIDONIC ACID
    • leukorienes-increase inflammation, prostaglandins-increase cap permeability, smooth muscle constriction and pain, thromnoxane-platelet avtivation, prostacyclines inhibits all the above
  10. Degranulation:
    release antimicrobial cytotoxic molecules
  11. Euosinophils :
    Creates and enzyme to destroy histamine "ANTIinflammatory", fights parasites.
  12. Natural Killer cells:
    designed to kill self cells, Virus kills the whole cells, they do not require a flag(M.H.C.)
  13. Cytokines are protein released by another cel: cell signaling
    • These are proteins released: 
    • Interleukins: pyrogen fever inducing substance
    • interferon: viral infections
  14. Plasma Protein Sytems essential to inflammatory response: Complement
    Sprinkles liver produces compliment adheres to external surfaces of all cells. A way to signal your immune system activates cells to die.
  15. Coagulation:
    making blood clot
  16. Kinin:
    is another pain simulator
  17. Interferons:
    help with viral infections, local manifestation, 4 cardinal signs, exudative-fluids out of your pipes, Serous-watery early acute, Fibrous-thick,clotted more advanced, Purulent-Nasty
  18. Exogenous:
    in bacteria infections
  19. Leukocytosis:
    High white blood cell count in leukocytes
  20. Adaptive Immunity: passive natural
    • fetus palcenta antibodies IGG
    • Breastmilk antibodies IGA
  21. Active Natural:
    Chickenpox exposed and make antibodies yourself.
  22. Passive artificial
    antibody therapy specific antibody to kill rabies
  23. Active Artificial
    vaccinations antigens and develop antibodies so you can have memory,
  24. Active
    self produce antibodies sou you can have memory
  25. Passive
    when antibodies are transferred.
  26. Antigen
    is a forein substace to the body that then produces and antibody to fight it
  27. B- cells
  28. t-cells
  29. B CEll
    MHC-2 connects to CD4, b-cell will differentiate into plasma cell to make antibodies or memory bcells
  30. T-cell
    MHC1 or MHC2 differentiate into 3 cells, memory t cells, th, or cytotoxic
Card Set
immune system
patho immune system
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