Card Set Information
patho immune system
Innate Imunne system:
Also known as non specific is the first line of defense. We were born with it, doesn't have antibodies.
Inflammatory response: innate immunity
second line of defense to injury or infection immediate broadly specific.
Third line of defense in response to antigen exposure, very specific, lymphocyte system, t and b lymphocytes
: prevents spreading
acute inflammation save your life
chronic can damage tissue 2 weeks death
Leukocyte: 1st innate
1st responder, most abundant, phagocytosis, chemotaxis, 1st 24 hours, not specific, diapedisis, pus.
after 24 hours, diapedisis, before no inflammation.
proinflammatory, produces histamine, most powerful cell. degranulation, constriction of smooth muscle, they activate ARACHIDONIC ACID
leukorienes-increase inflammation, prostaglandins-increase cap permeability, smooth muscle constriction and pain, thromnoxane-platelet avtivation, prostacyclines inhibits all the above
release antimicrobial cytotoxic molecules
Creates and enzyme to destroy histamine "ANTIinflammatory", fights parasites.
Natural Killer cells:
designed to kill self cells, Virus kills the whole cells, they do not require a flag(M.H.C.)
Cytokines are protein released by another cel: cell signaling
These are proteins released:
: pyrogen fever inducing substance
: viral infections
Plasma Protein Sytems essential to inflammatory response:
Sprinkles liver produces compliment adheres to external surfaces of all cells. A way to signal your immune system activates cells to die.
making blood clot
is another pain simulator
help with viral infections, local manifestation, 4 cardinal signs, exudative-fluids out of your pipes, Serous-watery early acute, Fibrous-thick,clotted more advanced, Purulent-Nasty
in bacteria infections
High white blood cell count in leukocytes
Adaptive Immunity: passive natural
fetus palcenta antibodies IGG
Breastmilk antibodies IGA
Chickenpox exposed and make antibodies yourself.
antibody therapy specific antibody to kill rabies
vaccinations antigens and develop antibodies so you can have memory,
self produce antibodies sou you can have memory
when antibodies are transferred.
is a forein substace to the body that then produces and antibody to fight it
MHC-2 connects to CD4, b-cell will differentiate into plasma cell to make antibodies or memory bcells
MHC1 or MHC2 differentiate into 3 cells, memory t cells, th, or cytotoxic