EXAM 3 carbohydrates glycocalyx Schiff base amadori and diabetes.txt

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Author:
rincrocci
ID:
286815
Filename:
EXAM 3 carbohydrates glycocalyx Schiff base amadori and diabetes.txt
Updated:
2014-10-23 17:09:17
Tags:
Applied nutrition
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Description:
Applied nutrition
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  1. Sucrose made of:
    Sucrose is a DI-saccharide mare from the mono-sacchardies: FRUCTOSE and GLUCOSE
  2. High fructose corn syrup
    • Fructose needs to be added to corn syrup in order to attain the same ratio of GlUCOSE to FRUCTOSE
    • This ratio is the same ratio present in SUCROSE (GlU + FRUC)
  3. Glycocalyx and function
    • Made of many GLUCOSE molecules branched together, attached to a PHOSPHOLIPID (look like a flower)
    • On cell surface:
    • 1.acts as SMOOTHENER to avoid sheer stress of cell-cell contact
    • 2.smooth surface helps avoid it from attack by macrophages, Bcells, neutrophils and dendridic cells
    • Carries a NEGATIVE CHARGE
    • This charge allows it to act with its primary function: ACT AS a buffer
    • 1. Neg charge allows the + charges (Mg and Ca) to be attracted to it
    • 2. Reduces ability of HIGHLY charged particles to move thru membrane
  4. Glycemic index
    • Shows INSULIN response
    • If diabetic, it will take much longer for glucose levels to get back down
    • Normally, after a meal, glucose is up, then by 90MIN it is back to normal levels
  5. Diabetes cause
    • Due to ADVANCED GLYCATION END PRODUCTS
    • Open chain GLUCOSE, specifically the aldehyde is the problem
    • This aldehyde reacts with NH2 of an AA to form SCHIFF Base
    • This SCHIFF Base can CONVERT to AMADORI Product --> which rearranges to the ADVANCED GLYCATION END PRODUCT (AGE)
    • AGEs cause rigid limbs and blood vessels, causing loss of limbs
  6. Schiff Base order of kinetics and how fast Amadori products are generated
    • 2nd order
    • 1/2 life of 2hrs, so by 6 hrs its gone from the blood
    • Schiff base REARRANGEMENT to Amadori product: takes WEEKS, so if you're not diabetic, Schiff Bases are not a concern for you

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