@ Early stages of development (~30 cells)
- 1. Initiation: one X is chosen
- (targeted for silencing)
- * It might be Xce ----> lots of genetic variation here
2. Spreading: As embryo is developing, compacting of chromatin begin at Xic, then moves along chromosome.
3. Maintenance:Through adulthood, each mitotic divisio, same x-chromosome (Barr body) is copied as such
* Barr Body *Some genes escape inactivation (example x-ist)