Which of the following diseases is characterized by an extremely high level of alkaline phosphatase, normal levels of calcium and phosphorus, enlargement of the skull, and an increased incidence of osteogenic sarcoma?
Paget's disease of bone
Paget's disease of bones is a chronic disorder that can result in enlarged and mis-shapen bones. Paget's is caused by the excessive breakdown and formation of bone, followed by disorganized bone remodelling. This causes affected bone to weaken, resulting in pain, misshapen bones, fractures and arthritis in the joints near the affected bones. Rarely forms Paget's sarcoma and is localized to some bones.