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The most common neoplasm of dairy cattle is ___________, and it is caused by a ___________, called __________.
lymphosarcoma; retrovirus; bovine leukemia virus
How is bovine leukemia virus spread between animals?
infected colostrum/milk (unpasteurized), direct physical contact with fluids (blood,saliva, milk/colostrum, nasal d/c, semen, urine), iatrogenic (contaminated instruments for vaccination, castration, dehorning), prenatal, insects
BLV is more prevalent in _________.
If an animal is infected with BLV, what are the 3 possible scenarios?
- Clinical lymphosarcoma (2%): tumors, clinical disease, death
- Persistent lymphocytosis (28%): no tumors, no disease
- Persistent infection (70%): no tumors, no lymphocytosis, no disease
What percent of cows infected with BLV end up with clinical lymphosarcoma?
What are tumor sites for lymphosarcoma from most common to least? (6)
lymph nodes, abomasum, heart (right atrium), urogenital, spinal cord, retrobulbar
The length of clinical disease before death depends on...
where the tumors are
Clinical findings associated with lymphosarcoma?
ADR, anorexia, decreased milk, lymphadenopathy (external, internal detected up rectal exam), GI symptoms (melena, abomasal obstruction, pyloric involvement, papple shaped), cardiovascular (congestive heart failure), spinal (paralysis), exophthalmos (eye protrudes because ln behind globe is involves)
What are the abnormalities you would find from the pathology reports associated with BLV?
persistent lymphocytosis, abnormal lymphocytes, increased lactate dehydrogenase, serology