Therapeutics - HIV 1

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Author:
kyleannkelsey
ID:
288004
Filename:
Therapeutics - HIV 1
Updated:
2014-11-03 14:39:18
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Therapeutics HIV
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Therapeutics - HIV
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Therapeutics - HIV
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  1. What are the risk factors for HIV?
    • Homosexual/bisexual men
    • IV drug use/abuse
    • sex partners in abuse groups
    • heterosexual men and women
    • Infants of above groups
  2. What are the Symptoms of HIV?
    • Fatigue/malaise
    • Lymphadenopathy
    • Weight loss
    • Fever
    • Night sweats
    • Diarrhea
    • Sore throat
  3. What labs indicate HIV?
    • CBC - decrease in WBC; decrease in H/H; decrease in platelets (slight)
    • T-cells subsets - prognostic valve (indirect)
    • T-helper (CD4) count (<500)
    • Skin-test anergy (can’t mount an immune response if they get a skin test of some sort)
    • Virology:
    • ELISA IgM or ELISA/Ag (Quick screening test)
    • Western blot – if negative - perform HIV viral load
  4. What drug is used to prevent HIV infection in high risk individuals?
    Truvada
  5. How do you prevent an HIV infection after an errant needle stick?
    • Decide whether to get treatment
    • Wash wound
    • Treatment (prophylaxis) - start ASAP (within 2 h)
    • Lasts 6 months if ELSIAs are all negative
    • ELISA - 0, 6 wks, 3 & 6 months
  6. What are the Nucleoside reverse transcriptase inhibitors?
    • Zidovudine - Retrovir
    • Didanosine - Videx
    • Lamivudine - Epivir
    • Stavudine - Zerit
    • Abacavir - Ziagen
    • Tenofovir-Viread
    • Emtricitabine-Emtriva
    • Abacavir+Lamivudine - Epzicom
    • Emtricitabine+Tenofovir DF – Truvada
    • Lamivudine+Zidovudine – Combivir
  7. What is the brand name for Zidovudine?
    Retrovir
  8. What is the brand name for Lamivudine?
    Epivir
  9. What is the brand name for Stavudine?
    Zerit
  10. What is the brand name for Tenofovir?
    Viread
  11. What is the brand name for Abacavir?
    Ziagen
  12. What is the brand name for Didanosine?
    Videx
  13. What is the brand name for Emtricitabine?
    Emtriva
  14. What is the brand name for Abacavir+Lamivudine?
    Epzicom
  15. What is the brand name for Emtricitabine+Tenofovir DF?
    Truvada
  16. What is the brand name for Lamivudine+Zidovudine?
    Combivir
  17. Nuceoside reverse transcriptase inhibitors need what to happen before they are active?
    Phosphorylation process (tri or di phosphorylation)
  18. What is the MOA of Nucleoside Reverse Transcriptase inhibitors?
    • Similar to Purines and Pyrimidines
    • Integrated in replication chain
    • Stop reverse transcriptase from replicating the DNA strand
    • Prevent formation of new virions
  19. What is the generic name for Retrovir?
    Zidovudine
  20. What is the generic name for Epivir?
    Lamivudine
  21. What is the generic name for Zerit?
    Stavudine
  22. What is the generic name for Ziagen?
    Abacavir
  23. What is the generic name for Viread?
    Tenofovir
  24. What is the generic name for Videx?
    Didanosine
  25. What is the generic name for Emtriva?
    Emtricitabine
  26. What is the generic name for Epzicom?
    Abacavir+Lamivudine
  27. What is the generic name for Truvada?
    Emtricitabine+Tenofovir DF
  28. What is the generic name for Combivir?
    Lamivudine+Zidovudine
  29. How often is Abacavir (ABC) given?
    BID or QD
  30. What is Abacavir metabolized by?
    • EtOH dehydrogenase
    • EtOH leads to elevated ABC
  31. What are the major risks of taking Abacavir?
    • Cardiac events
    • Potentially fatal hypersensitivity reactions (Fever/Rash/N/V, Anorexia, SOB, cough, sore throat)
  32. How can you avoid Hypersensitivity reactions associated with Abacavir?
    • Screen for HLA B*5701
    • Homozygous + or Heterozygous + are likely to have a hypersensitivity rxn
    • 100% positive predictive value for the rxn
  33. What combination therapy should be avoided with Abacavir?
    TDF

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