Diseases Part 3

• - need to consume it (fecal oral spread)
• - toxin causes salt channels in colon to fail, causing release of water
• - early on, its fecal and malodorous
• - rice water stool due to protein metabolism

• -20% of body weight lost
•   people below age 12 and above age 70

- death due to dehydration

• sunken eyes and cheeks, rapid and weak or missing pulse
• - water comes out of circ system--> increased viscosity of blood--> harder to pump--> renal system screwed up--> liver failure

• death in less than 12 hours
• colonize GI tract

acidosis is secondary to protein metabolism

- Neisseria gonorrhoea: bacteria enters via direct contact of discontinuous epithelium 

- OP proteins allow it to avoid the immune system

- immunogenic: body builds immunity against it, but gonorrhoea can live inside WBC (don't get digested by lytic enzymes)

- repeated infections: pH of pus is so acidic that the smoothness of the urinary tract turns into topographic surface; pus plug forms--? can't release pus or urine

all get it

• - cankers; bleed a bit and release bacteria
• transfer through thin or discontinuous epithelium
• witlow: non sexually transmitted lesion that forms if the bacteria gets into an open wound

• no cankers
• dermatologic; lacy red rash
• syphilids: small, raised lesions about size of dime

--> can cause hyperreactivity in connective tissue near infection

• extremely rare
• - syphilid like lesions
• - dermatologic presentation; syphilid lke lesions (gumma usually on extremities due to small amount of connective tissue

• -> neurosyphilis: fulid-filled cysts in brain-->dementia/ parkinson like syndrome
• --> localized foci of necrosis, which become the cysts

cardiosyphilis: thinning of walls of great vessels around heart--> teasing bv--> protruding aneurysms taht may result in death

can cause secondary infections (gummata)

perforation of hard palette

cat's eye

sabre shin: one bowled shin

Hutchinson's teeth

deformed nasal bridge

• deepst cancre
• most painful
• men usually ahve one to four
• women usualyl have one to seven 

painful; erode the CT and use toxin from bacteria

sexually and non-sexually