- immune response
- repeated infections?
- Neisseria gonorrhoea: bacteria enters via direct contact of discontinuous epithelium
- OP proteins allow it to avoid the immune system
- immunogenic: body builds immunity against it, but gonorrhoea can live inside WBC (don't get digested by lytic enzymes)
- repeated infections: pH of pus is so acidic that the smoothness of the urinary tract turns into topographic surface; pus plug forms--? can't release pus or urine