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DesLee26
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Cholera
- way to et in
- toxin
- early on
- effects
- - need to consume it (fecal oral spread)
- - toxin causes salt channels in colon to fail, causing release of water
- - early on, its fecal and malodorous
- - rice water stool due to protein metabolism
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Result of having cholera
- problem for who?
death due to?
- appearance of individual
- -20% of body weight lost
- people below age 12 and above age 70
- death due to dehydration
- sunken eyes and cheeks, rapid and weak or missing pulse
- - water comes out of circ system--> increased viscosity of blood--> harder to pump--> renal system screwed up--> liver failure
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Death rate?
colonize?
secondary?
- death in less than 12 hours
- colonize GI tract
acidosis is secondary to protein metabolism
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Gonorrhoea
- species
- proteins
- immune response
- repeated infections?
- Neisseria gonorrhoea: bacteria enters via direct contact of discontinuous epithelium
- OP proteins allow it to avoid the immune system
- immunogenic: body builds immunity against it, but gonorrhoea can live inside WBC (don't get digested by lytic enzymes)
- repeated infections: pH of pus is so acidic that the smoothness of the urinary tract turns into topographic surface; pus plug forms--? can't release pus or urine
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Syphilis
- primary stage
all get it
- - cankers; bleed a bit and release bacteria
- transfer through thin or discontinuous epithelium
- witlow: non sexually transmitted lesion that forms if the bacteria gets into an open wound
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Syphilis
- second stage
- no cankers
- dermatologic; lacy red rash
- syphilids: small, raised lesions about size of dime
--> can cause hyperreactivity in connective tissue near infection
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Tertiary form of the disease
- extremely rare
- - syphilid like lesions
- - dermatologic presentation; syphilid lke lesions (gumma usually on extremities due to small amount of connective tissue
- -> neurosyphilis: fulid-filled cysts in brain-->dementia/ parkinson like syndrome
- --> localized foci of necrosis, which become the cysts
cardiosyphilis: thinning of walls of great vessels around heart--> teasing bv--> protruding aneurysms taht may result in death
can cause secondary infections (gummata)
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Rare complication of syphilis
perforation of hard palette
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Congenital Syphilis
cat's eye
sabre shin: one bowled shin
Hutchinson's teeth
deformed nasal bridge
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Chancroid
- deepst cancre
- most painful
- men usually ahve one to four
- women usualyl have one to seven
painful; erode the CT and use toxin from bacteria
sexually and non-sexually
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