What is peptic ulcer disease? etiologies? pathophysiology? difference b/t gastric and duodenal? CM?
- It is the disorder of the upper GI tract caused by the action of acid and pepsin.
- Ulcers usually found in the esophagus, stomach, or duodenum.
- Etiologies: 70% of them H. pylori and NSAIDs.
- Patho: Gastric and duodenal ulcer.
- Gastric: Caused by the breakdown of protective mucous layer (treat with drugs to protect the mucousa linning)
- Duodenal: Excess of secretion of acid (treat w drugs that block the formation of HCL, H2 inhibitors)
- CM: melena is associated w upper GI, and red is Lower GI bleeds.
- Duodenal ulcer: feel better when they eat or antiacids. gain weight.
- Gastric: pain occurs in empty stomach, food doesn't relieve pain. loose weight.