Genetics Test 2 ch17

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DSB
- Double-Strand Breaks (DSB)
- Bad ----> Most deleterious types of mutations.
DSB Repair

NHEJ and HRR
NHEJ
- non-homologous end joining
- May fill in w/ polymerase Ligate
- *From a cell's perspective better to have a small deletion than (DSB)
- initiation chromosomal rearrangement
- *NHEJ can happend @ any stage in cell cycle
HRR
- Homologous Recombination Repair
- -more complex than NHEJ needs a homolous sequence (sister chromatids)
- - uses sister chromatids to repair DSB
- *Usually error-free
- - Common during S and G2
Homologous Recombination
- 1. Meiosis, necessary fir segregation of chromosomes.
- 2. Promotes genetic diversity
- 3. Help repair DNA
Figure 17.5

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HRR Process
- 1. Proteins recognize DSB
- 2. Proteins that do "end-processing" --->often 5' to 3' exonuclease "
- 3. Proteins that aid in "strand invasion"
- 4. DNA Polymerase
- *New DNA Synthesis
- 5. unwind broken DNA strand from template and anneal back in place with ligase
HRR non-recombinate result
HRR w/ recombinant