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Genetics Test 2 ch17
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DSB
Double-Strand Breaks (DSB)
Bad ----> Most deleterious types of mutations.
DSB Repair
NHEJ and HRR
NHEJ
non-homologous end joining
May fill in w/ polymerase Ligate
*From a cell's perspective better to have a small deletion than (DSB)
initiation chromosomal rearrangement
*NHEJ can happend @ any stage in cell cycle
HRR
Homologous Recombination Repair
-more complex than NHEJ needs a homolous sequence (sister chromatids)
- uses sister chromatids to repair DSB
*Usually error-free
- Common during S and G2
Homologous Recombination
1. Meiosis, necessary fir segregation of chromosomes.
2. Promotes genetic diversity
3. Help repair DNA
Figure 17.5
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HRR Process
1. Proteins recognize DSB
2. Proteins that do "end-processing" --->often 5' to 3' exonuclease "
3. Proteins that aid in "strand invasion"
4. DNA Polymerase
*New DNA Synthesis
5. unwind broken DNA strand from template and anneal back in place with ligase
HRR non-recombinate result
HRR w/ recombinant
Author
doncheto
ID
288648
Card Set
Genetics Test 2 ch17
Description
DBS
Updated
11/10/2014, 9:48:33 PM
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