Genetics Test 2 ch17

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Author:
doncheto
ID:
288648
Filename:
Genetics Test 2 ch17
Updated:
2014-11-10 16:48:33
Tags:
Double strand repair NHE HRR
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Description:
DBS
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  1. DSB
    • Double-Strand Breaks (DSB)
    • Bad ----> Most deleterious types of mutations.
  2. DSB Repair
    NHEJ and HRR
  3. NHEJ
    • non-homologous end joining 
    • May fill in w/ polymerase Ligate
    • *From a cell's perspective better to have a small deletion than (DSB)

    • initiation chromosomal rearrangement
    • *NHEJ can happend @ any stage in cell cycle
  4. HRR
    • Homologous Recombination Repair
    • -more complex than NHEJ needs a homolous sequence (sister chromatids)
    • - uses sister chromatids to repair DSB
    •   *Usually error-free
    • - Common during S and G2
  5. Homologous Recombination
    • 1. Meiosis, necessary fir segregation of chromosomes.
    • 2. Promotes genetic diversity
    • 3. Help repair DNA
  6. Figure 17.5
    *********fdsakjfskjfgw****
  7. HRR Process
    • 1. Proteins recognize DSB
    • 2. Proteins that do "end-processing" --->often 5' to 3' exonuclease "
    • 3. Proteins that aid in "strand invasion"
    • 4. DNA Polymerase 
    •     *New DNA Synthesis
    • 5. unwind broken DNA strand from template and anneal back in place with ligase
  8. HRR non-recombinate result
  9. HRR w/ recombinant

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