1) What happens to the clots themselves?
They are dissolved. Fibrin is split by plasmin, a serine protease that hydrolyzes peptide bonds in the coiled-coil region. Plasmin molecules diffuse through aqueous channels to cut the accessible fibrin connector rods. Plasmin’s activation from plasminogen is activated by tissue-type plasminogen activator (TPA). When TPA is bound to fibrin clots, it activates adhering plasminogen, not free plasminogen