Card Set Information
RhoGAM must be given w/in ___ hrs of delivery
MOA of RhoGAM
neutralizes mother's Rh+ antigens so they won't attack baby
what disease does RhoGAM treat? how effective is it?
hemolytic disease of newborn
which receptor does cyclosporine bind to?
cyclosporine blocks the fxn of ____ in order to reduce IL-2 synthesis
cyclosporine reduces: IL-1, IL-2 or IL-5 synthesis
what diseases is cyclosporine used for?
major s/e of cyclosporine
tacrolimus and rapamycin bind to which receptor?
binds to immunophilin to reduce IL-2 synthesis
cyclosporine and tacrolimus both decrease ___ synthesis
tacrolimus is used to treat which conditions?
tacrolimus is more or less nephrotoxic than cyclosporine?
tacrolimus is more or less nephrotoxic than rapamycin?
binds to immunophilin to inhibit mTOR and stop cell cycle
which is associated with lymphoproliferative disorders: RhoGAM, cyclosporine or tacrolimus?
which drug is associated with impaired wound healing?
when should tacrolimus and rapamycin be used together?
never (bind same receptor)
what is everolimus used for?
cardiac allograft vasculopathy
post transplant lymphoproliferative disorders
2 MOA's of fingolimod
1st: S1P1R binding -->receptor internalization and reduced lymphocyte migration
2nd: sequestration of peripheral lymphocytes into secondary tissues
CTLA-4 inhibits T cell activation by binding CD80/86
which drug is used for kidney/liver rejection prophylaxis?
which drug is associated w/CNS lymphoproliferative disorders?
belatacept can only be given to which type of patients?
how does belatacept differ from abatacept?
2 amino acids
what is abatacept used for?
MOA of steroids
-block IL-2 transcription
-inhibit adhesion molecule fxn
-inhibit T cell proliferation
what diseases are treated by high and low doses of steroids?
high: acute graft rejection
low: acute GVHD
what is azathioprine used for?
-prevention of transplant rejection
mycophenolate is selective for which type(s) of cells? how?
B and T cells
only cells that use de novo pathway
which cytotoxic agent inhibits glycosylation of adhesion molecules?
mycophenolate should NOT be administered with:
what is mycophenolate used for?
which cytotoxic agent is associated with hepatotoxicity?
methotrexate (low doses, alcohol)
lymphocyte immune globulins inhibit which type(s) of cells?
2 s/e of lymphocyte immune globulins
-cytokine release syndrome
-post-transplant lymphoproliferative disorders
symptoms of cytokine release syndrome
-flu-like (fever, chills)
lymphocyte immune globulins are associated with lymphomas in which type(s) of cells?
which cytotoxic drug is a polyclonal antibody?
lymphocyte immune globulins
which cytotoxic drug treats acute kidney rejection?
lymphocyte immune globulin
non-specifically alkylates DNA to both inhibit and stimulate different T cell responses
why is cyclophosphamide more toxic than mycophenolate?
it non-specifically affects cell DNA, whereas mycophenolate is selective for B and T cells
cyclophosphamide is more toxic to which type(s) of cells?
B cells (recover slower)
intercalates into DNA in dark and modifies it in UV light to kill T cells
resistant T cell lymphoma