Immunosuppresive drugs

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Immunosuppresive drugs
2014-11-10 20:06:38
Immunosuppresive drugs
Immunosuppresive drugs
Immunosuppresive drugs
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  1. RhoGAM must be given w/in ___ hrs of delivery
  2. MOA of RhoGAM
    neutralizes mother's Rh+ antigens so they won't attack baby
  3. what disease does RhoGAM treat? how effective is it?
    hemolytic disease of newborn
  4. 100%
  5. which receptor does cyclosporine bind to?
  6. cyclosporine blocks the fxn of ____ in order to reduce IL-2 synthesis
  7. cyclosporine reduces: IL-1, IL-2 or IL-5 synthesis
  8. what diseases is cyclosporine used for?
    • tissue transplantation
    • autoimmune
    • GVHD
  9. major s/e of cyclosporine
  10. tacrolimus and rapamycin bind to which receptor?
  11. tacrolimus MOA
    binds to immunophilin to reduce IL-2 synthesis
  12. cyclosporine and tacrolimus both decrease ___ synthesis
  13. tacrolimus is used to treat which conditions?
    tissue transplantation
  14. tacrolimus is more or less nephrotoxic than cyclosporine?
  15. tacrolimus is more or less nephrotoxic than rapamycin?
  16. rapamycin MOA
    binds to immunophilin to inhibit mTOR and stop cell cycle
  17. which is associated with lymphoproliferative disorders: RhoGAM, cyclosporine or tacrolimus?
  18. which drug is associated with impaired wound healing?
  19. when should tacrolimus and rapamycin be used together?
    never (bind same receptor)
  20. what is everolimus used for?
    • cardiac allograft vasculopathy
    • post transplant lymphoproliferative disorders
  21. 2 MOA's of fingolimod
    1st: S1P1R binding -->receptor internalization and reduced lymphocyte migration

    2nd: sequestration of peripheral lymphocytes into secondary tissues
  22. belatacept MOA
    CTLA-4 inhibits T cell activation by binding CD80/86
  23. which drug is used for kidney/liver rejection prophylaxis?
  24. which drug is associated w/CNS lymphoproliferative disorders?
  25. belatacept can only be given to which type of patients?
    EBV seropositive
  26. how does belatacept differ from abatacept?
    2 amino acids
  27. what is abatacept used for?
    refractory RA
  28. MOA of steroids
    • -block IL-2 transcription
    • -inhibit adhesion molecule fxn
    • -inhibit T cell proliferation
  29. what diseases are treated by high and low doses of steroids?
    high: acute graft rejection

    low: acute GVHD
  30. what is azathioprine used for?
    • -autoimmune diseases
    • -prevention of transplant rejection
  31. mycophenolate is selective for which type(s) of cells? how?
    • B and T cells
    • only cells that use de novo pathway
  32. which cytotoxic agent inhibits glycosylation of adhesion molecules?
  33. mycophenolate should NOT be administered with:
    • Mg/Al antacids
    • cholestyramine
  34. what is mycophenolate used for?
    kidney transplants
  35. which cytotoxic agent is associated with hepatotoxicity?
    methotrexate (low doses, alcohol)
  36. lymphocyte immune globulins inhibit which type(s) of cells?
    T cells
  37. 2 s/e of lymphocyte immune globulins
    • -cytokine release syndrome
    • -post-transplant lymphoproliferative disorders
  38. symptoms of cytokine release syndrome
    • -flu-like (fever, chills)
    • -hypotension
  39. lymphocyte immune globulins are associated with lymphomas in which type(s) of cells?
    B cells
  40. which cytotoxic drug is a polyclonal antibody?
    lymphocyte immune globulins
  41. which cytotoxic drug treats acute kidney rejection?
    lymphocyte immune globulin
  42. cyclophosphamide MOA
    non-specifically alkylates DNA to both inhibit and stimulate different T cell responses
  43. why is cyclophosphamide more toxic than mycophenolate?
    it non-specifically affects cell DNA, whereas mycophenolate is selective for B and T cells
  44. cyclophosphamide is more toxic to which type(s) of cells?
    B cells (recover slower)
  45. methoxsalen MOA
    intercalates into DNA in dark and modifies it in UV light to kill T cells
  46. methoxsalen indication
    resistant T cell lymphoma