Bone is primarily _____________, which has two components, which are.....
extracellular matrix; organic component and inorganic component (can't ID on histo slide)
Mesenchymal cells that synthesize osteoid and mediate its mineralization; line bone surfaces.
When osteoblasts become trapped in bone, they become __________.
Mesenchymal cells which represent largely inactive osteoblasts trapped within formed bone; may assist in nutrition of bone.
Mesenchymal cells that are phagocytic cell which are capable of eroding bone; important in constant turnover of bone.
Osteocytes reside in ___________.
As osteoid is laid down, osteoblasts become trapped in _________ as ___________, and their fine cytoplasmic processes are contained within ___________.
lacunas; osteocytes; canaliculi
During Phase 1 of osteoblast secretory activity, the ___________ is formed through synthesis and secretion of ___________.
osteoid seam; organic materials
Phase 2 of osteoblast secretory activity is the __________ of the ___________.
mineralization; osteoid seam
During Phase 2 of osteoblast activity, __________ from the osteoblast Golgi is released in vesicles; calcium is pumped into the vesicles, causing crystals to _________, which causes the ___________. The crystals deposit and progress to _________.
hydroxyapetite; precipitate; vesicle to burst; diffuse mineralization
Haphazard deposition of osteoid during period of rapid growth leads to temporary ________.
Compact collagen fiber arrangement in which all collagen fibers go in the same direction.
lamellar bone (ALL normal bone in adults)
Two macroscopic structures of bone.
compact bone and trabecular (cancellous) bone
Compact bone is located at areas where _______________________, such as ________________.
densely packed bone mass is needed; cortices of long bones
Trabecular (cancellous) bone is in the ____________ of bones and provides ______________.
center of bones (surrounded by compact bone); strength in all directions with minimal mass
__________ acts as initiator of bone deposition.
What are the 2 layers of periosteum?
fibrous layer (with vessels and nerves), osteogenic (cambium) layer
When periosteum is quiescent, osteoprogenitor cells are _________; when new bone is actively being formed, osteoprogenitors ________ and become ________.
flat and lie on the periosteal surface; proliferate and grow; osteoblasts
Surface on the inside of the bone.
Multi-nucleated, large, macrophage-derived cells; primarily responsible for the removal of mineralized bone.
_________ binds to RANK and activates it on the surface of an ________, causing it to ____________. Then, the __________ moves away so the _________ can bind and remove mineralized bone.