Therapeutics - HIV 5

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Author:
kyleannkelsey
ID:
288949
Filename:
Therapeutics - HIV 5
Updated:
2014-11-11 21:30:21
Tags:
Therapeutics HIV
Folders:
Therapeutics - HIV
Description:
Therapeutics - HIV
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  1. What type of drug is Emtricitabine-Emtriva?
    NRTI
  2. What type of drug is Abacavir+Lamivudine - Epzicom?
    NRTI
  3. What type of drug is Emtricitabine+Tenofovir DF – Truvada?
    NRTI
  4. What type of drug is Lamivudine+Zidovudine – Combivir?
    NRTI
  5. What type of drug is Nevirapine – Viramune?
    NNRTI
  6. What type of drug is Delavirine – Rescriptor?
    NNRTI
  7. What type of drug is Maraviroc?
    CCR5 co-receptor antagonist (Fusion Inhibitor)
  8. What are the Fusion inhibitors?
    Maraviroc and Enfuvirtide
  9. What is the generic name for Fuzeon?
    Enfuvirtide
  10. What is the brand name for Enfuvirtide?
    Fuzeon
  11. What is the brand name for Maraviroc?
    Selzentry
  12. What is the generic name for Selzentry?
    Maraviroc
  13. What type of drug is Efavirenz – Sustiva?
    NNRTI
  14. What type of drug is Atripla (tenofovir + emtricitabine + efavirenz)?
    NNRTI
  15. What type of drug is Etravirine – Intelence?
    NNRTI
  16. What type of drug is Rilpivirine – Edurant?
    NNRTI
  17. What type of drug is Complera (tenofovir + emtricitabine +rilpivirine)?
    NNRTI
  18. Atazanavir has better or worse Bioavailability with food?
    Better
  19. How is Atazanavir metabolized?
    Metabolized by P4503A inhibitor/substrate
  20. What are the SE for Atanazivir?
    hyperbilirubinemia – (jaundice); HA; rash; GI symptoms; 1st degree A-V block; hyperglycemia; fat maldistribution
  21. What is the preferred boosted-PI by DHHS guidelines?
    Daranavir
  22. Daranavir will be used along with ___________.
    ritonavir
  23. Daranavir should be given with or without food?
    With
  24. Daranavir can be used with what type of HIV virus?
    Used for wild-type and PI-resistant virus
  25. What are the SE of Daranavir?
    • Hepatitis; S-J syndrome; TEN; HA (15%); N (18%); diarrhea (20%)
    • Contains sulfa moiety – rash
  26. How is Daranavir metabolized?
    by CYP3A
  27. Fosamprevavir is effected by food in what way?
    No food effect
  28. What CYP interactions does Fosamprevavir have?
    CYP4503A inducer/inhibitor/substrate
  29. What are the SE of Fosamprevavir?
    • rash 19% S-J syndrome; headache; hyperlipid; fat maldistribution;
    • Sulfa moiety – rash
  30. Indinavir has what CYP interaction?
    P4503A inhibitor
  31. Indinavir has what SE?
    Nephrolithiasis (kidney stones); GI intol; hyperbilirubinemia; hyperlipid; hyperglycemia; fat maldistribution; headache; blurred vision; rash; red. PLTs
  32. Lopinavir+Ritonavir should be taken with or without food?
    Mod. Fat meal elevates AUC 48% and 80% (caps/solution)
  33. What CYP effects does Lopinavir+Ritonavir have?
    P4503A inhibitor
  34. What SE does Lopinavir+Ritonavir have?
    GI intol; hyperlipid; elevated LFTs; hyperglycemia; fat maldistribution
  35. Nelfinavir should be taken with or without meals?
    Concs. Increase 2-3 fold – take w/meals
  36. Nelfinavir has what CYP effects?
    P4503A inhibitor/substrate
  37. Nelfinavir has what SE?
    diarrhea; hyperlipid; hyperglycemia; fat maldistribution; elevated LFTs
  38. Tipranavir is not recommended in what group and why
    • Not recommended in tx-naïve pts.
    • Use for People to fall back on if they develop resistance

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