Therapeutics - HIV 4

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Author:
kyleannkelsey
ID:
288950
Filename:
Therapeutics - HIV 4
Updated:
2014-11-11 21:30:30
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Therapeutics HIV
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Therapeutics - HIV
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Therapeutics - HIV
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  1. What are the SE of Tipranavir?
    • Hepatic impairment
    • Intracranial hemorrhage
    • Rash
    • GI effects – N, V, D
  2. PIs have what effect on Azoles?
    Increase Azole concentrations
  3. PIs have what effect on Clarithromycin?
    Increase Clarithromycin concentrations
  4. PIs have what effect on PPIs?
    Decrease PPI concentrations (may be equally effective though)
  5. PIs have what effect on Opioids?
    Increase opioid levels
  6. PIs have what effect on antiarrhythmics?
    Increase antiarrhythmic levels
  7. PIs have what effect on anticonvulsants?
    Reduce concentration of anticonvulsants and PI
  8. What other drugs are CI with PIs?
    • Rifampin
    • Rifabutin
    • Benzodiazapines
  9. What effect do PIs have on Warfarin?
    Increase levels
  10. What effect do PIs have on statins?
    Increase levels
  11. What are the Non-Nucleoside Reverse transcriptase inhibitors?
    • Nevirapine - Viramune
    • Delavirine - Rescriptor
    • Efavirenz – Sustiva
    • Atripla (tenofovir + emtricitabine + efavirenz)
    • Etravirine - Intelence
    • Rilpivirine – Edurant
    • Complera (tenofovir + emtricitabine +rilpivirine)
  12. What is the brand name for Nevirapine?
    Viramune
  13. What is the brand name for Delavirine ?
    Rescriptor
  14. What is the brand name for Efavirenz?
    Sustiva
  15. What is the brand name for tenofovir + emtricitabine + efavirenz?
    Atripla
  16. What is the brand name for Etravirine?
    Intelence
  17. What is the brand name for Rilpivirine?
    Edurant
  18. What is the brand name for tenofovir + emtricitabine +rilpivirine?
    Complera
  19. What is the generic name for Viramune?
    Nevirapine
  20. What is the generic name for Rescriptor?
    Delavirine
  21. What is the generic name for Sustiva?
    Efavirenz
  22. What is the generic name for Atripla?
    Tenofovir + emtricitabine + efavirenz
  23. What is the generic name for Intelence?
    Etravirine
  24. What is the generic name for Edurant?
    Rilpivirine
  25. What is the generic name for Complera?
    Tenofovir + emtricitabine +rilpivirine
  26. Delavirdine should be separated by 1 hr from what other drugs?
    Didanosine or antacids
  27. How is Delavirdine effected by food?
    No food effect
  28. How is Delavirdine metabolized?
    By P4503A (inhibitor); 51% excreted in urine (as metabolites)
  29. What are the SE of Delavirdine?
    rash; elevated LFTs; headache
  30. Use of DLV is not recommended due to:
    High pill burden, dose frequency, SE and DDIs
  31. Efavirenz has good or bad bioavailability?
    Poor 42%
  32. How is Efavirenz metabolized?
    By P4503A (mixed inducer/inhibitor)
  33. What are the SE of Efavirenz?
    • Rash; CNS symptoms (52%) = Suicide ideation; elevated LFTs; false + cannabinoid test; teratogenic in monkeys (try not to use in 1st trimester)
    • Probably shouldn’t use with schizophrenia or depression
  34. Is Efavirenz used as an initial therapy?
    Yes, commonly
  35. Nevirapine has good or bad bioavailability?
    Good 90%
  36. What is Nevirapine metabolized by?
    P4503A (inducer)
  37. What are the SE of Nevirapine?
    Rash (37%); S-J syndrome; hepatitis; fatal hepatic necrosis particularly in women (pregnancy)
  38. Entravirine has in vitro activity against what?
    NNRTI-resistant strains
  39. Entravirine should be taken with or without food?
    • With
    • CYP450 3A4 inducer
    • Toxicity: rash 9%; S-J syndrome; nausea 13%
  40. Is Entravirine used initially?
    Not usually, usually just used in NNRTI-resistant strains
  41. Rilpiverine is usually combined with what other drugs?
    Tenofovir + emtricitabine
  42. What group of patients is Rilpiverine usually used in?
    • Ttreatment naïve pts
    • VL < 100,000
  43. What are the SE of Rilpiverine?
    Depression (4%), insominia, headache (3%), and rash (3%)
  44. What drug requires a viral oad of < 100,000?
    Rilpiverine
  45. Cross resistance to efavirenz, etravirine, and/or nevirapine is likely after development of resistance to _________.
    rilpivirine

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