Therapeutics - HIV 2

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Author:
kyleannkelsey
ID:
288952
Filename:
Therapeutics - HIV 2
Updated:
2014-11-11 21:30:47
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Therapeutics HIV
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Therapeutics - HIV
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Therapeutics - HIV
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  1. Didanosine is not recommended as initial therapy due to:
    Aadverse rxns
  2. What are the SE of Didanosine?
    • Pancreatitis (+ D4T); peripheral neuropathy; nausea; diarrhea;
    • lactic acidosis (rare but life threatening – NRTIs class effect)
  3. What NTRIs can cause Lactic acidosis?
    All
  4. Is Emtricitabine used for initial therapy?
    Yes
  5. Does Emitricitabine effected by food consumption?
    No food effect
  6. Does Emtricitabine have poor or good Bioavailability?
    Good (93%)
  7. What drugs should Emtricitabine not be used with?
    Lamivudine (3TC) – Too similar
  8. What are the SE of Emtricitabine?
    • Toxicity – minimal
    • HA, N/V, diarrhea – occasionally
    • Lactic acidosis with hepatic steatosis
  9. Lamivudine has what bioavailability and T ½?
    • Bioavail = 86%
    • T1/2intra=18-22 hrs
  10. What is Lamivudine also used to treat?
    Hepatitis B
  11. What are the SE of Lamivudine?
    Toxicity – lactic acidosis
  12. When would you use Stavudine?
    • Rarely
    • Not recommended by DHHS due to side effects
  13. How is Stavudine excreted?
    Renal excretion -50%
  14. What are eth SE of Stavidine?
    • Toxicity: lipodystrophy (highest incidence); hyperlipidemia; lactic acidosis
    • Do not use D4T + ddI together (CIPregnancy)
  15. Is Tenofovir recommended for initial therapy?
    Yes
  16. How is Tenofovir excreted?
    Renal excretion
  17. What are the SE of Tenofovir?
    Toxicity: headache; N/V; diarrhea; renal insuff; lactic acidosis
  18. Is Tenofovir used very much?
    Yes
  19. Zidovudine is metabolized how?
    • In liver
    • Glucuronidation
  20. What are the SE of Zidovudine?
    Toxicity: bone marrow suppression (CI Hgb < 8); GI intolerance; insomnia; lactic acidosis
  21. Are protease inhibitors usually used alone?
    No often boosted with Ritonavir
  22. How are most PI metabolized?
    CYP3A
  23. When you give Ritonavir with PIs what activity are you using it for?
    Inhibit metabolism of the PI (not used as an antiretroviral)
  24. PI inhibitors should be taken with or without food?
    With a moderate to high fat meal (eggs/bacon/sausage/gravy)
  25. What are the protease inhibitors?
    • Indinavir - Crixivan
    • Nelfinavir - Viracept
    • Ritonavir – Norvir
    • Lopinavir/Ritonavir – Kaletra
    • Fosamprenavir - Lexiva
    • Atazanavir – Reyataz
    • Tipranavir – Aptivus
    • Darunavir – Prezista
  26. What is the brand name for Indinavir?
    Crixivan
  27. What is the brand name for Nelfinavir ?
    Viracept
  28. What is the brand name for Ritonavir?
    Norvir
  29. What is the brand name for Lopinavir/Ritonavir?
    Kaletra
  30. What is the brand name for Fosamprenavir?
    Lexiva
  31. What is the brand name for Atazanavir?
    Reyataz
  32. What is the brand name for Tipranavir?
    Aptivus
  33. What is the brand name for Darunavir?
    Prezista
  34. What is the generic name for Crixivan?
    Indinavir
  35. What is the generic name for Viracept?
    Nelfinavir
  36. What is the generic name for Norvir?
    Ritonavir
  37. What is the generic name for Kaletra?
    Lopinavir/Ritonavir
  38. What is the generic name for Lexiva?
    Atazanavir
  39. What is the generic name for Reyataz?
    Fosamprenavir
  40. What is the generic name for Aptivus?
    Tipranavir
  41. What is the generic name for Prezista?
    Darunavir
  42. What type of drug is Indinavir – Crixivan?
    PI
  43. What type of drug is Nelfinavir - Viracept?
    PI
  44. What type of drug is Raltegravir – Isentress ?
    Integrase inhibitor
  45. What type of drug is Dolutegravir – Tivicay?
    Integrase inhibitor
  46. What type of drug is Dolutegravir abacavir/lamivudine – Triumeq?
    Integrase inhibitor
  47. What type of drug is Elvitegravir – Stribild (quad pill)?
    Integrase inhibitor
  48. What type of drug is Cobicistat – Tybost ?
    Integrase inhibitor/Enzyme inhibitor for p450 system ?
  49. What type of drug is Elvitegravir – Vitekta?
    Integrase inhibitor
  50. What type of drug is Ritonavir – Norvir?
    PI
  51. What type of drug is Lopinavir/Ritonavir – Kaletra?
    PI
  52. What type of drug is Fosamprenavir - Lexiva?
    PI
  53. What type of drug is Atazanavir – Reyataz?
    PI
  54. What type of drug is Tipranavir – Aptivus?
    PI
  55. What type of drug is Darunavir – Prezista?
    PI
  56. What type of drug is Zidovudine – Retrovir?
    NRTI
  57. What type of drug is Didanosine - Videx?
    NRTI
  58. What type of drug is Lamivudine - Epivir?
    NRTI
  59. What type of drug is Stavudine - Zerit?
    NRTI
  60. What type of drug is Abacavir - Ziagen?
    NRTI
  61. What type of drug is Tenofovir-Viread?
    NRTI

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