Name the exemplars (antihypertensives) and action for ACE/ARBs, BB, Ca+ channel blocker, and Diuretics (thiazide, loop, and K+ sparing)
ACE: captoril (inhibits AI-->AII by inhibiting ACE = decrease); contains Alpha 1/Alpha 2
ARBs: losartan (blocks AII from binding to its receptors on blood vessels)
BB: metoprolol (B1 & B2); selective only for B1; Non-selective for both B1 & B2.
Ca++: diltiazem; inhibits movement of Ca++ into muscles-->decreases contraction-->decreases BP.
- Thiazide: HCTZ; blocks Cl- pump in distal tubule excreting Cl- & Na+.
- Loop: furosemide; works in loop of Henle to inhibit reabsorption of Na+ & Cl-.
- K+ sparing: triamterene; weak when used alone, promotes Na+ & H2O excretion in distal tubule while retaining K+.