Explain the patch clamp experiment.
You go into the cell that has acetylcholine receptors and use a glass pipette to grab the piece fo membrane with receptors.
Another way is going into the cell and poking a hole
an electrode is stuck inside nad outside the pipette. A voltage is applied and the current is mesured. Depending on resistance, the current will change.
Result: when channels close, the current needs to pass through the membrane. High resistance.
When the channels open, there is lower resistance and it goes in easiy