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Primary clinical uses of neuromuscular blocking agents
- *To facilitate endotracheal intubation
- *To obtain muscle relaxation during surgery, particularly of the thorax and abdomen
- *To enhance patient-ventilator synchrony
- *To reduce intracranial pressure in intubated patients with uncontrolled intracranial pressure
- *To reduce oxygen consumption
- *To terminate convulsive status epilepticus and tetanus in patient refractory to other therapies
- *To facilitate procedures or diagnostic studies
- *To paralyze patients who must remain immobile (e.g., trauma patients)
Define Nondepolarizing Agents
*Agents that paralyze skeletal muscle by simple competitive inhibition of Ach at muscle receptor site.
List the depolarizing agents:
Succinylcholine is the only available agent in the group.
Define depolarizing agents:
Agents to open sodium channels and depolarize the postsynaptic muscle membrane in the same manner as Ach
Maximal paralyzing effects of nondepolarizing agents are reached in _____ minutes?
1 to 3
The effects of nondepolarizing blocking agents can be reversed by:
the use of cholinesterase inhibitors, such as neostigmine
Succinylcholine would be to patients...
Benefits of neuromuscular paralysis in ventilator management include:
- *improved ventilation
- *improved oxygenation
- *not fighting vent