problems w translation

Card Set Information

Author:
chartreuse
ID:
289770
Filename:
problems w translation
Updated:
2014-11-21 00:20:14
Tags:
translation problems
Folders:
Molecular Bio
Description:
translation problems
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  1. stalled ribosomes
  2. non-stop or truncated mRNA 
    - caused by...(2)
    - effects...(2)
    • defective transcription
    • mutation = no stop codon or read-through

    • nucleolytic degradation: 
    • - truncated proteins
    • - stalled ribosome
  3. truncated proteins are usually:
    non-functional, dominant negative phenotypes, toxic
  4. prokaryotic stalled ribosome rescue mechanism
    - structure & function
    • transfer-messanger RNA (tmRNA) - combo
    • - mimics tRNAAla = aminoacyl tRNA synthetase (aaRS) transfers Ala
    • - middle of tmRNA has short (10aa) peptide used to tag truncated proteins for degradation

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