Levodopa AE: Nausea and vomiting (have it w food),
Selegiline: Can supress destruction of dopamine derived from levodopa and prolong the effects of dopamine.
PT: May take several weeks to see beneficial effects -- change position slowly -- take w food -- Do not discontinue drugs -- Avoid the use of alcohol -- AE: if the movement increases or gets worse, maybe there is something else going on.
Alzheimer's Disease drugs? SE
Cholinesterase inhibitors: Donepezil (aricept), Galantamine (razadyne), Rivastigmine (exelon) also used in PD, Tacrine (causes liver damage).
SE of cholinesterase inh: GI (nausea, vomiting, diarrhea), dizziness, headache, bronchoconstriction, liver injury (tacrine).
Multiple Sclerosis (MS) drugs? AE?
drugs: Immunomodulators and immunosuppresants (short course of high-dose IV glucocorticoids) -- Natalizumab (tysabril) used in MS and Crohn's disease.
Immunomodulators: recreate the immune system to not recognize there is an inflammatory response (interferon beta-1a (avonex, Rebif) 1b (betaseron), etc)
AE: interferon beta could cause for flu-like rxn(give late in day -- might premedicate w tylenol).
There are drugs to manage all the symptoms of MS.
Epilepsy drug types? MOA? drugs names, SE, and serum drug level (SDL)?
Drugs types: Traditional antiepilectic drugs (AEDs) and newer AEDs.
MOA: Supression of sodium influx, suppression of calcium influx, antagonism of glutamate, potentiation of GABA.
Phenytoin (dilantin): 8 to 60 hrs of half-life -- used as a antiHTN drug -- AE: sedation, cognitive impairment, CV effects (hypotension- HR increase), gingina hyperplasia -- SDL: 10 to 20 mcg/ml