Microbio final Pt 2

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  1. Stages of Viral Infection
    • Penetration
    • Uncoating
    • Replication/ Latency
    • Transcription
    • Protein Synthesis
    • Assembly and Maturation
    • Release
  2. Attachment
    Attachment site on virus attaches to complementary receptor site on bacterial cell
  3. Penetration

    The virus does what?
    Enveloped virus
    This __
    Naked virus
    Enters how? 
    __ bring the virus in
    Virus “__” in
    T-even phase __, which releases __, which __
    __remains outside
    • enters the cell
    • Envelope fuses with the host membrane
    • propels that capsid into the host cell
    • Spikes bind to the host cells
    • Host receptors
    • pushes
    • inject DNA with tail
    • phage lysozyme
    • breaks down a portion of the cell wall
    • Capsid
  4. Uncoating
    • Occurs after the virus enters the host
    • Capsid proteins break down
    • Release genetic material into the host cytoplasm
  5. Replication/ Latency

    The viral genome enters the __
    Copies of the genome are __ and __; __ is stopped by __, __, or __
    Host cell’s ribosomes, enzymes, and amino acids are used for __
    The __ is the period when when complete, infective virions are not yet present
    The genome __
    May reactivate later
    If reactivation occurs copies of the genome are made and released onto the cytoplasm
    • host nucleus
    • made and released onto the cytoplasm
    • host protein synthesis
    • virus-induced degradation of the host DNA
    • viral proteins that interfere with transcription
    • repression of translation
    • translation
    • eclipse period
    • intercalates into the host genome
  6. mRNA is made from the __
    Three types of genes? 
    Viral mRNA results in the __
    viral genome

    • early, intermediate, late
    • synthesis of various viral proteins
  7. Assembly and Maturation

    New viruses are packed into __; assembled into __; spontaneous
    __, __, and other proteins
    __ done
    Progeny viruses move to inner side of the host plasma membrane
    • partially completed capsids
    • complete virions
    • Genome, RT
    • Packing 
    • Capsid
  8. Release

    Progeny viruses escape from the host.

    Explain enveloped and naked.
    enveloped: Progeny bud as they wrap themselves in a small piece of the host plasma membrane

    naked: Push through the host plasma membrane; Lyses the host plasma membrane. This results in the death of the host.
  9. Lysogenic Cycle
    • Some viruses do not cause lysis and death upon multiplication
    • These lysogenic phages may proceed through a lytic cycle, but can incorportate themselves into DNA as well
    • Lysogeny: inactive
  10. Reinfection
    the cycle may begin again
  11. Replication Strategy of a DNA virus
    invasion and uncoating--> parental DNA--> mRNA--> proteins--> progeny DNA--> mRNA--> protein--> progeny virus
  12. Replication Strategy of a - strand RNA Virus
    Invasion and Uncoating--> - strand parental DNA-->

    1) using virion enzymes, + mRNA is made--> progeny virus

    2) + strand RNA template--> - strand progeny RNA--> progeny virus
  13. Replication Strategy of a + strand RNA Virus
    Invasion and Uncoating--> + strand parental DNA-->

    1) mRNA is made--> proteins encoded by entire genome--> progeny virus

    2) + strand RNA template--> + strand progeny RNA--> progeny virus
    cancer-causing alterations to cellular DNA that affects parts of genomes
  15. oncogenic viruses
    viruses capable of inducing tumors in animals
  16. tumor cells undergo __, meaning what

    they acquire properties different from properties of uninfected cells or from infected cells that don't make tumors
  17. Latent infection
    when a virus can remain in equilibrium with host and not produce disease for a long period
  18. persistent/ chronic viral infection
    occurs gradually over time; can be fatal
  19. prions
    proteinaceous infectious particle
  20. plant viruses
    similar to animal with similar types of NAs; cause diseases of economically important crops
  21. viroids
    short pieces of naked RNA with no protein coat
Card Set:
Microbio final Pt 2
2014-11-26 16:53:39
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