schizophrenia etiologies? pathophysiology? Clinical manifestations?
- etiologies: chemical imbalance (dopamine and glutamate) -- the dopamine hypothesis: dopamine 1 and 2. -- genetic factors -- exposure to virus during gestation.
- Patho: genetic predisposition and environmental factors. Changes in the hippocampus, temporal lobes, and dopamine pathways that go to the limbic system.
- CM: Positive, negative, and cognitive symptoms.
- Positive symptoms: excessive Dopamine 2 (hallucinations, delusions, diorganized speech, etc)
- Neg. Sym.: Mediated by dopamine 1 (loss of interest, social withdrawal, autism)
- Cog. Symp: memory probs and inability to sustain attention.