Ch 17 Lecture 3
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Because __ is used in the cell, it can be taken from the CAC. This loss in __ is checked by __, which helps to make sure energy remains how?
- pyruvate carboxylase
- by converting pyruvate to oxaloacetate
Oxaloacetate is the building block of which amino acids?.
other amino acids, such as aspartic acid, methionine, threonine, isoleucine, lysine, and asparagine.
also makes purines and pyrimidines
Succinyl CoA is important in what?
- porphyrins require 2 succinyl coA
- 4 porphyrins make a heme; require 8 succinyl coA
Alpha-ketoglutarate is what?
an intermediate that can be removed to make several amino acids
glutamate--> glutamine, proline, arginine
Pyruvate--> acetyl CoA-->citrate--> __
fatty acids, sterols
Glucose to pyruvate?
Fatty acids being fed into the CAC as acetyl CoA is what type of reaction?
fatty acid oxidation
alpha-ketoglutarate-> CO2 and H2O is hwat?
Beri beri is caused by ?
dietary deficiencies in vitamin B1; problem for eastern cultures where rice is the main staple
neuroplogical and cadiac disorder characterized by anorexia, enlargement of the heart, paresthesia, muscle weakness and weariness
Beri beri causes what?
deficiency in thiamine, which is the precursor to the prosthetic group TPP
What is TPP important for?
pyruvate dehydrogenase, transketolase, alpha-ketoglutarate
Arsenite causes what?
- causes build up of alpha ketoglutarate
- simiar to effects of Hg or As poisoning
What is treatment OF this?
ingest something that competes with binding of arsenite, gets rid of it thorugh urination.
Why is oxygen necessary for the Krebs Cycle?
regeneration of NADH and FADH2
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