NSAIDs - Pharmacology

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Author:
Pandora320
ID:
290358
Filename:
NSAIDs - Pharmacology
Updated:
2014-12-02 04:34:10
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Pharmacology
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Description:
Pharmacology PAP-570
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  1. Has the gastroprotective features
    Prostocyclins
  2. Pain that cox-2 works on
    Throbbing
  3. Cox2 inhibitor on the market
    Celecoxib
  4. Most common complaint when using indomethacin
    Frontal HA
  5. Not an NSAID
    Acetominophin
  6. Only one that be administered IV or IM
    Ketorolac
  7. Don’t give in 3rd trimester
    Ibuprofen
  8. Contraindicated in pregnancy
    Indomethacin
  9. Good for PDA
    Indomethacin
  10. Is a prodrug
    Nabumatone
  11. What kind of risk does naproxen carry
    cardiovascular
  12. Protection and maintenance function. Cannot be induced. Cox 1 or Cox2?
    1
  13. Proinflammatory and mitgenic effects. Can be induced
    COX-2
  14. Given in a once daily dose
    Nabumatone
  15. What initiates the prostaglandin cascade
    Phospholipase A2
  16. Are prostaglandins stored? What does this mean for release?
    No. in order for prostaglandins to be released they need to be synthesized
  17. Do anti-inflammatory NSAIDS block the effect or the number of inflammatory cells
    Effect
  18. Inhibiting PGE2, causes what effect
    Antipyretic effect
  19. Risk with long-term use of NSAIDs and acetaminophen
    Hepatotoxicity
  20. Is there a chronic effect with aspirin chronic use
    No
  21. Onset and efficacy of analgesic effects are comparable to morphine
    Ketorolac
  22. Salycilic acid category drugs
    Aspirin, diflunisal
  23. Delays partrition in 3rd trimester
    Ibuprofen
  24. Which one causes irreversible cox inhibition
    Aspirin
  25. 10g can cause hepatotoxicity
    Acetaminophen
  26. Most potent inhibitor of COX
    Indomethacin
  27. Must be stopped 1 week before surgery and why
    Aspirin. Increased INR time. Irreversibly acetylates COX and inhibits platelet synthesis of Thromboxane A2, which is required for platelet aggregation
  28. Which drug has poor antipyretic effects? Why?
    Diflunisal. It can't penetrate the CNS well.
  29. No anti-inflammatory effect
    Acetaminophen
  30. Proprionic acid derivative drugs
    Ibuprofen, naproxen
  31. Cause of fatal poisoning in children
    Aspirin
  32. Acetic acid drugs
    Indomethacin, ketorolac, Nabumetone
  33. Cox2 inhibitor drugs
    Celecoxib, rofecoxib
  34. Reason why rofecoxib/Cox2 have been pulled from the market (mechanism/pathophys)
    By only impacting the COX-2 -mediated PGI2 prostacyclin, there is an imbalance between thromboxane A2 in the platelets and prostacyclin in the vascular wall, leading to a net prothrombotic state
  35. Removed from the market
    rofecoxib
  36. May cause peptic ulcer disease or renal failure if used more than 5 days
    Ketorolac
  37. Can only be used OTC for 10 days
    Naproxen

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