Addiction - Pharmacology

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Which way does “tolerance” shift the dose-response curve

Right
Which way does “sensitization” shift the curve

left
Who should be screened on substance abuse Everyone
What is the #1 cause of relapse

Cravings
What are the 3 stages of abuse dependence

1.development 2. Maintenance 3. Persistence
Is withdrawal fatal with opioids

No
Is withdrawal fatal with alcohol

Yes- gran mal seizures
Is OD fatal with opioids

Yes
Is OD fatal with alcohol

No
What happens when you mix alcohol with other drugs

Increase risk of fatality
What is the most fatal substance known to man kind

Alcohol and cocaine
Madarosis

Searing off eyelashes and eyebrows from cocaine smoke
If you see nasal perforation on routine exam be suspicious for use of this drug

Cocaine
What are the steps of cocaine withdrawal

Crash, withdrawal, extinction
How do you differentiate cocaine from amphetamine use?

Cocaine only lasts for 1 hr. amphetamine is longer
Drugs where you see auditory hallucinations

PCP/ketamine/dextromethorphan
How do you tx barbiturate and hypnotic withdrawal

Substitute long-acting benzos and gradually taper dose
How do you treat alchohol withdrawal

Benzos to attenuate withdrawal symptoms. Naltrexone once all alcohol is out of body. Disulfiram. Acamprosate
How does disulfiram work

Inhibits aldehyde dehydrogenase. Causes accumulation of acetylaldehyde which is toxic and causes adverse effects like vomiting
How do you treat nicotine withdrawal

Nicotine transdermal patch. Buproprion. Varencicline.
How does buproprion work

Weak inhibitor of dopamine uptake
Hoes does varencicline work

It’s a partial agonist of nicotine receptors?
How do you tx someone addicted to more than once substance

Tx both the addictions

Author:	Pandora320
ID:	290359
Card Set:	Addiction - Pharmacology
Updated:	2014-12-01 20:46:58
Tags:	Pharmacology
Folders:
Description:	Pharmacology PAP-570
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