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Addiction - Pharmacology
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Which way does “tolerance” shift the dose-response curve
Right
Which way does “sensitization” shift the curve
left
Who should be screened on substance abuse Everyone
What is the #1 cause of relapse
Cravings
What are the 3 stages of abuse dependence
1.development 2. Maintenance 3. Persistence
Is withdrawal fatal with opioids
No
Is withdrawal fatal with alcohol
Yes- gran mal seizures
Is OD fatal with opioids
Yes
Is OD fatal with alcohol
No
What happens when you mix alcohol with other drugs
Increase risk of fatality
What is the most fatal substance known to man kind
Alcohol and cocaine
Madarosis
Searing off eyelashes and eyebrows from cocaine smoke
If you see nasal perforation on routine exam be suspicious for use of this drug
Cocaine
What are the steps of cocaine withdrawal
Crash, withdrawal, extinction
How do you differentiate cocaine from amphetamine use?
Cocaine only lasts for 1 hr. amphetamine is longer
Drugs where you see auditory hallucinations
PCP/ketamine/dextromethorphan
How do you tx barbiturate and hypnotic withdrawal
Substitute long-acting benzos and gradually taper dose
How do you treat alchohol withdrawal
Benzos to attenuate withdrawal symptoms. Naltrexone once all alcohol is out of body. Disulfiram. Acamprosate
How does disulfiram work
Inhibits aldehyde dehydrogenase. Causes accumulation of acetylaldehyde which is toxic and causes adverse effects like vomiting
How do you treat nicotine withdrawal
Nicotine transdermal patch. Buproprion. Varencicline.
How does buproprion work
Weak inhibitor of dopamine uptake
Hoes does varencicline work
It’s a partial agonist of nicotine receptors?
How do you tx someone addicted to more than once substance
Tx both the addictions
Author:
Pandora320
ID:
290359
Card Set:
Addiction - Pharmacology
Updated:
2014-12-01 20:46:58
Tags:
Pharmacology
Folders:
Description:
Pharmacology PAP-570
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