Therapeutics - T2DM 2

Card Set Information

Author:
kyleannkelsey
ID:
290381
Filename:
Therapeutics - T2DM 2
Updated:
2014-12-01 20:04:03
Tags:
Therapeutics T2DM
Folders:
Therapeutics - T2DM
Description:
Therapeutics - T1DM
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user kyleannkelsey on FreezingBlue Flashcards. What would you like to do?


  1. Liraglutide (Victoza) has what MOA?
    • Human GLP-1 analogue similar to extenatide
    • Incretin mimetic
    • Stimulates the production of insulin in response to high glucose concentrations.
    • Inhibition of the release of glucagon after meals.
    • Slows the rate of gastric emptying.
  2. Liraglutide (Victoza) is the same as ____________ with an added C-16 fatty acid chain increases half-life
  3. How often is Liraglutide (Victoza) dosed?
    once daily dosing
  4. What is the most common adverse effect of Liraglutide (Victoza)?
    Nausea (10.5%-40%)
  5. What is the efficacy of Liraglutide (Victoza)?
    Decreases A1C ~ 1.0% at 1.8 mg/day
  6. Why do you use dose escalation from 0.6 mg/day for one week, increased by 0.6 mg per week to a maximum of 1.8 mg/day when initiating Liraglutide (Victoza)?
    Reduce GI effects
  7. Is Liraglutide (Victoza) used in renal failure?
    No dosage adjustment for renal impairment
  8. How should you make up for missed doses of Liraglutide (Victoza)?
    Do not make up for missed doses
  9. What are the AE for Liraglutide (Victoza)?
    • Thyroid c-cell tumors and pancreatitis
    • Patients with thyroid nodules or elevated serum calcitonin levels should be referred to an endocrinologist
  10. What should you monitor when a patient is taking Liraglutide (Victoza)?
    S/S of pancreatitis at initiation and with dose increases
  11. Exenatide-ER (Bydureon) comes in what dosage form?
    • Injectable suspension
    • Available in a premixed pen
  12. How does Exenatide-ER (Bydureon) compare to Byetta and Victoza?
    • More effective than Byetta (0.9% vs. 1.6% A1C); similar to liraglutide
    • Less nausea (~15%) than either Byetta or liraglutide
    • Less expensive than Liraglutide
  13. How is Exenatide-ER (Bydureon) dosed?
    • Any time of the day
    • 2 mg SQ once every 7 days without regard to food
  14. What are the SE/Precautions of Exenatide-ER (Bydureon)?
    • Bumps at injection site; dissipates within weeks
    • Caution with renal impairment
    • Weight loss (same as for all incretins) 6-8 pounds over 6 months
    • Pancreatitis
    • Risk of thyroid c-cell tumors
  15. What is Exenatide-ER (Bydureon)CI in?
    Personal or family history of medullary thyroid carcinoma
  16. What are the disadvantages of Exenatide-ER (Bydureon)?
    Expensive
  17. What are the main advantages of Exenatide-ER (Bydureon)?
    • Less expensive than Liraglutide
    • May be:
    • More effective than prandial insulin when combined with basal
    • More effective than insulin glargine?
    • May be a good alternative to basal insulin (A1C ≥ 8.5%) for those concerned with weight gain, risk of hypoglycemia, and QD injections
  18. What patient population may Exenatide-ER (Bydureon) be particularly useful in?
    May be a good alternative to basal insulin (A1C ≥ 8.5%) for those concerned with weight gain, risk of hypoglycemia, and QD injections
  19. ________________________ should be injected immediately after powder becomes suspended.
    Exenatide-ER (Bydureon)
  20. What is the MOA of Exenatide-ER (Bydureon)?
    • Incretin mimetic
    • Stimulates glucagon-like peptide 1 receptor
    • Stimulates the production of insulin in response to high glucose concentrations.
    • Inhibition of the release of glucagon after meals.
    • Slows the rate of gastric emptying.
  21. Albiglutide (Tanzeum) comes in what dosage form?
    Injectable suspension in a pen similar to Bydureon
  22. What is a normal dose of Albiglutide (Tanzeum)?
    • 30 mg SQ Q week (abdomen, thigh, upper arm)
    • Administer same time each day without regard to meals
    • May increase to 50 mg Q wk if inadequate response
    • Day of weekly administration may be changed as long as last dose was 4 or more days before
  23. How should you make up for missed doses of Albiglutide (Tanzeum)?
    • Administer ASAP within 3 days after the missed dose
    • If more than 3 days after the missed dose, wait until next regularly scheduled weekly dose
  24. Should Albiglutide (Tanzeum) be used in renal failure?
    No dosage adjustment for renal impairment
  25. What are the most common AE/precautions for Albiglutide (Tanzeum)?
    • ≥ 10% URTI, diarrhea, nausea, injection site reaction
    • Risk of thyroid c-cell tumors and pancreatitis
    • (Patients with thyroid nodules or elevated serum calcitonin levels should be referred to an endocrinologist)
    • Pancreatitis
  26. What should you monitor for with Albiglutide (Tanzeum)?
    Monitor for S/S of pancreatitis at initiation and with dose increases
  27. What drugs should you monitor for S/S of pancreatitis at initiation and with dose increases?
    Incretin mimetics, Exenatide, Liraglutide, Albigultide and Dulaglutide
  28. Dulaglutide (Trulicity) is administered in what way?
    • Inject SQ Q week at any time of day
    • Initiate at 0.75 mg Q week; can increase to 1.5 mg/week
  29. Can Dulaglutide (Trulicity) be given in renal impairment?
    No dosage adjustment with renal dysfunction
  30. What is Dulaglutide (Trulicity) approved for?
    • Monotherapy or in combination with metformin, sulfonylurea, TZD, and prandial insulin
    • Not considered first-line therapy
  31. What are the Contraindications of Dulaglutide (Trulicity)?
    • T1DM
    • Ketoacidosis
    • Severe GI disorders
    • Personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2
  32. What are the Warnings and Precautions for Dulaglutide (Trulicity)?
    • Thyroid C-cell tumors in animals
    • Pancreatitis
  33. Hypoglycemia - use lower dose when combined with insulin or insulin
  34. What should you monitor for with Dulaglutide (Trulicity)?
    Renal function in patients with impairment; worsen GI effects
  35. What are the Side effects of Dulaglutide (Trulicity)?
    Nausea, diarrhea, vomiting, abdominal pain, and decreased appetite

What would you like to do?

Home > Flashcards > Print Preview